Analysis Tools
endocrine/exocrine glands
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• mutants exhibit delayed involution, such that at 3 days after pup removal, compaction of alveoli and loss of epithelial cells is not observed as in wild-type
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• up to day 3 postpartum, the epithelial cells lining the alveoli appear more flattened compared to the cuboidal epithelium of wild-type mice
• maturation of fully functional secretory alveoli occurs earlier than in wild-type mice, with alveolar size increased to a greater extent than in wild-type by 6 days of lactation and epithelial cells even more flattened
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• no differences in the ductal tree of virgin and early pregnant mice, however by 14 days of pregnancy, the lobuloalveolar structures are expanded and appear more developed
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• epithelial cells lining the alveoli of lactating females appear more flattened compared to the cuboidal epithelium of wild-type mice
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• 7.5% of multiparous transgenic mice develop mammary tumors
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• mice are able to lactate, however milk contains higher levels of milk proteins (alpha-casein, beta-casein, and gamma-casein), resulting in a more rapid weight increase of pups than observed with wild-type mothers
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reproductive system
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• no differences in the ductal tree of virgin and early pregnant mice, however by 14 days of pregnancy, the lobuloalveolar structures are expanded and appear more developed
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neoplasm
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• 7.5% of multiparous transgenic mice develop mammary tumors
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integument
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• mutants exhibit delayed involution, such that at 3 days after pup removal, compaction of alveoli and loss of epithelial cells is not observed as in wild-type
|
|
|
• up to day 3 postpartum, the epithelial cells lining the alveoli appear more flattened compared to the cuboidal epithelium of wild-type mice
• maturation of fully functional secretory alveoli occurs earlier than in wild-type mice, with alveolar size increased to a greater extent than in wild-type by 6 days of lactation and epithelial cells even more flattened
|
|
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• no differences in the ductal tree of virgin and early pregnant mice, however by 14 days of pregnancy, the lobuloalveolar structures are expanded and appear more developed
|
|
|
• epithelial cells lining the alveoli of lactating females appear more flattened compared to the cuboidal epithelium of wild-type mice
|
|
• 7.5% of multiparous transgenic mice develop mammary tumors
|
|
|
• mice are able to lactate, however milk contains higher levels of milk proteins (alpha-casein, beta-casein, and gamma-casein), resulting in a more rapid weight increase of pups than observed with wild-type mothers
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