Phenotypes associated with this allele

• Allele Symbol: Lta/Tnf^tm1Fda
• Allele Name: targeted mutation 1, Francois Dautry
• Allele ID: MGI:2447729
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lta/Tnf^tm1Fda/Lta/Tnf^tm1Fda	involves: 129S1/Sv * 129X1/SvJ	MGI:3768392
ht2	Lta/Tnf^tm1Fda/Tnf^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3768394

Genotype
MGI:3768392

hm1

• Allelic Composition: Lta/Tnf^tm1Fda/Lta/Tnf^tm1Fda
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased tumor necrosis factor secretion ( J:39519 )

• mice do not produce detectable TNF-alpha in response to treatment with 100 ug LPS unlike wild-type mice

decreased susceptibility to endotoxin shock ( J:39519 )

• mice survive doses of LPS and D-galactosamine that are three orders of magnitude higher than doses that would kill wild-type mice

increased susceptibility to bacterial infection ( J:39519 )

• bacterial load is 1000- and 50-fold higher than wild-type in the liver and spleen, respectively

Genotype
MGI:3768394

ht2

• Allelic Composition: Lta/Tnf^tm1Fda/Tnf⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

immune system

decreased tumor necrosis factor secretion ( J:39519 )

• mice produce 60-fold less TNF-alpha in response to treatment with 100 ug LPS than wild-type mice

decreased susceptibility to endotoxin shock ( J:39519 )

• at low doses of LPS and D-galactosamine lethality is 30% compared to 60% in wild-type mice and a high doses lethality is only increased slightly

increased susceptibility to bacterial infection ( J:39519 )

• bacterial load in the liver and spleen are 20- and 4-fold higher, respectively, than in wild-type mice but not as high as in homozygotes