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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikzf1tm1.1(Pax5)Mbu
targeted mutation 1.1, Meinrad Busslinger
MGI:2447787
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ikzf1tm1.1(Pax5)Mbu/Ikzf1+ involves: 129P2/OlaHsd * C57BL/6 MGI:2653528
cn2
 		Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:3804204


Genotype
MGI:2653528
ht1
Allelic
Composition		 Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm1.1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:118111 )
• mice die between 2 and 4 months of age

hematopoietic system
thymus hypoplasia ( J:118111 )
• significantly reduced at 2 weeks relative to Ightm1(PAX5)Mbu homozygotes
abnormal erythropoiesis ( J:80815 )
• number of erythroid precursors in bone marrow decreases to 1/20 of control numbers by 8 weeks of age
increased pro-B cell number ( J:80815 )
• at 8 weeks, number of pro-B cells is still 3.5-fold greater than controls
decreased double-positive T cell number ( J:118111 )
• significantly reduced at 2 weeks relative to Ightm1(PAX5)Mbu homozygotes
increased B cell number ( J:80815 )
• at E18.5, there are ~7-fold more B lymphocytes than in controls

immune system
thymus hypoplasia ( J:118111 )
• significantly reduced at 2 weeks relative to Ightm1(PAX5)Mbu homozygotes
increased pro-B cell number ( J:80815 )
• at 8 weeks, number of pro-B cells is still 3.5-fold greater than controls
decreased double-positive T cell number ( J:118111 )
• significantly reduced at 2 weeks relative to Ightm1(PAX5)Mbu homozygotes
increased B cell number ( J:80815 )
• at E18.5, there are ~7-fold more B lymphocytes than in controls

neoplasm
increased lymphoma incidence ( J:118111 )
• lymphoid organs show diffuse infiltration by diffuse lymphoblastic lymphoma
• extensive tumor infiltrates are found in other organs including heart, kidneys, lungs, liver, intestine and testis

endocrine/exocrine glands
thymus hypoplasia ( J:118111 )
• significantly reduced at 2 weeks relative to Ightm1(PAX5)Mbu homozygotes

growth/size/body
enlarged spleen ( J:118111 )




Genotype
MGI:3804204
cn2
Allelic
Composition		 Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
Ikzf1tm1.1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137719 )
N
• development of pro-B cells is rescued
abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory