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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lin7btm1Dsb
targeted mutation 1, David S Bredt
MGI:2447804
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lin7btm1Dsb/Lin7btm1Dsb involves: 129X1/SvJ * C57BL/6J MGI:3582547
cx2
 		Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb 		either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J) MGI:3582546
cx3
 		Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3639323
cx4
 		Lin7atm1Dsb/Lin7a+
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3639324


Genotype
MGI:3582547
hm1
Allelic
Composition		 Lin7btm1Dsb/Lin7btm1Dsb
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3582546
cx2
Allelic
Composition		 Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb
Genetic
Background		 either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation (0 available); any Lin7a mutation (23 available)
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype

nervous system
nervous system phenotype ( J:68187 )
N
• although carefully examined, no abnormalities were identified in synaptic transmission




Genotype
MGI:3639323
cx3
Allelic
Composition		 Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation (0 available); any Lin7a mutation (23 available)
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
Lin7ctm1Dsb mutation (0 available); any Lin7c mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:102649 )
• mice die within one hour of birth

nervous system
abnormal excitatory postsynaptic currents ( J:102649 )
• in culture, neurons from triple knock out mice show reduced EPSCs relative to wild-type

respiratory system
abnormal breathing pattern ( J:102649 )
• mice exhibit irregular, labored breathing




Genotype
MGI:3639324
cx4
Allelic
Composition		 Lin7atm1Dsb/Lin7a+
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation (0 available); any Lin7a mutation (23 available)
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
Lin7ctm1Dsb mutation (0 available); any Lin7c mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:102649 )
• mice die during second week postnatal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory