About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lin7btm1Dsb
targeted mutation 1, David S Bredt
MGI:2447804
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lin7btm1Dsb/Lin7btm1Dsb involves: 129X1/SvJ * C57BL/6J MGI:3582547
cx2
 		Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb 		either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J) MGI:3582546
cx3
 		Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3639323
cx4
 		Lin7atm1Dsb/Lin7a+
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3639324


Genotype
MGI:3582547
hm1
Allelic
Composition		 Lin7btm1Dsb/Lin7btm1Dsb
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3582546
cx2
Allelic
Composition		 Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb
Genetic
Background		 either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation (0 available); any Lin7a mutation (23 available)
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype

nervous system
nervous system phenotype ( J:68187 )
N
• although carefully examined, no abnormalities were identified in synaptic transmission




Genotype
MGI:3639323
cx3
Allelic
Composition		 Lin7atm1Dsb/Lin7atm1Dsb
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation (0 available); any Lin7a mutation (23 available)
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
Lin7ctm1Dsb mutation (0 available); any Lin7c mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:102649 )
• mice die within one hour of birth

nervous system
abnormal excitatory postsynaptic currents ( J:102649 )
• in culture, neurons from triple knock out mice show reduced EPSCs relative to wild-type

respiratory system
abnormal breathing pattern ( J:102649 )
• mice exhibit irregular, labored breathing




Genotype
MGI:3639324
cx4
Allelic
Composition		 Lin7atm1Dsb/Lin7a+
Lin7btm1Dsb/Lin7btm1Dsb
Lin7ctm1Dsb/Lin7ctm1Dsb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin7atm1Dsb mutation (0 available); any Lin7a mutation (23 available)
Lin7btm1Dsb mutation (0 available); any Lin7b mutation (13 available)
Lin7ctm1Dsb mutation (0 available); any Lin7c mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:102649 )
• mice die during second week postnatal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory