Analysis Tools
mortality/aging
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• following LMCV infection, mice exhibit an increased survival
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• mice become moribund at 8 to 12 months of age
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nervous system
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• mice exhibit a dilation of blood vessels and endothelial cell hypertrophy in the brain
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• mice exhibit a predominantly lymphocyte infiltration in the brain
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• meningoencephalitis
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• ependymal cells lining the ventricles exhibit swelling and irregular configurations of their cell surface
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• epithelial cells of the choroids plexus exhibit swelling and irregular configurations of their cell surface
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• at 10 to 12 months of age, mice exhibit calcification in the basal ganglia
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• at 10 to 12 months of age, mice exhibit calcification in the cerebellum
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• calcifications in the granule layer consists of concentric and often laminated deposits
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• at 10 to 12 months of age, mice exhibit calcification in the cerebellum and basal ganglia
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astrocytosis
(
J:68811
)
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• mice exhibit degeneration of myelinated axons
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behavior/neurological
immune system
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• mice exhibit a predominantly lymphocyte infiltration in the brain
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• meningoencephalitis
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• following LMCV infection, mice exhibit decreased brain pathology and increased viral clearance compared to similarly treated wild-type mice
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• following LMCV infection, mice exhibit an increased survival
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growth/size/body
weight loss
(
J:68811
)
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• at 8 to 12 months of age
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cardiovascular system
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• mice exhibit a dilation of blood vessels and endothelial cell hypertrophy in the brain
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