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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat2tm1Shnd
targeted mutation 1, Christian Schindler
MGI:2447829
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat2tm1Shnd/Stat2tm1Shnd involves: 129S1/Sv * 129X1/SvJ MGI:3029261
cx2
 		Stat1tm1Rds/Stat1tm1Rds
Stat2tm1Shnd/Stat2tm1Shnd 		involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:4441310


Genotype
MGI:3029261
hm1
Allelic
Composition		 Stat2tm1Shnd/Stat2tm1Shnd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat2tm1Shnd mutation (3 available); any Stat2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:66564 )
• after a dexamethasone challenge, mutants exhibit a substantial repopulation of the CD4/CD8 double-positive compartment within 2-5 days whereas wild-type mice only show an increase in their CD8+ population
increased susceptibility to Riboviria infection ( J:66564 )
• mutants succumb to vesicular stomatitis virus (VSV) infection with doses that are about 6 logs lower than in controls
• primary embryonic fibroblasts infected with VSV produce about 40 times more virus than wild-type cells
• IFN-alpha treatment afforded no protection against VSV infection as in wild-type

hematopoietic system
abnormal T cell differentiation ( J:66564 )
• after a dexamethasone challenge, mutants exhibit a substantial repopulation of the CD4/CD8 double-positive compartment within 2-5 days whereas wild-type mice only show an increase in their CD8+ population




Genotype
MGI:4441310
cx2
Allelic
Composition		 Stat1tm1Rds/Stat1tm1Rds
Stat2tm1Shnd/Stat2tm1Shnd
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Rds mutation (4 available); any Stat1 mutation (74 available)
Stat2tm1Shnd mutation (3 available); any Stat2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Riboviria infection ( J:66564 )
• mutants succumb to vesicular stomatitis virus (VSV) infection quicker than wild-type or single homozygous mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory