About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat2tm1Shnd
targeted mutation 1, Christian Schindler
MGI:2447829
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat2tm1Shnd/Stat2tm1Shnd involves: 129S1/Sv * 129X1/SvJ MGI:3029261
cx2
 		Stat1tm1Rds/Stat1tm1Rds
Stat2tm1Shnd/Stat2tm1Shnd 		involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:4441310


Genotype
MGI:3029261
hm1
Allelic
Composition		 Stat2tm1Shnd/Stat2tm1Shnd
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat2tm1Shnd mutation (3 available); any Stat2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:66564 )
• after a dexamethasone challenge, mutants exhibit a substantial repopulation of the CD4/CD8 double-positive compartment within 2-5 days whereas wild-type mice only show an increase in their CD8+ population
increased susceptibility to Riboviria infection ( J:66564 )
• mutants succumb to vesicular stomatitis virus (VSV) infection with doses that are about 6 logs lower than in controls
• primary embryonic fibroblasts infected with VSV produce about 40 times more virus than wild-type cells
• IFN-alpha treatment afforded no protection against VSV infection as in wild-type

hematopoietic system
abnormal T cell differentiation ( J:66564 )
• after a dexamethasone challenge, mutants exhibit a substantial repopulation of the CD4/CD8 double-positive compartment within 2-5 days whereas wild-type mice only show an increase in their CD8+ population




Genotype
MGI:4441310
cx2
Allelic
Composition		 Stat1tm1Rds/Stat1tm1Rds
Stat2tm1Shnd/Stat2tm1Shnd
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1tm1Rds mutation (4 available); any Stat1 mutation (74 available)
Stat2tm1Shnd mutation (3 available); any Stat2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to Riboviria infection ( J:66564 )
• mutants succumb to vesicular stomatitis virus (VSV) infection quicker than wild-type or single homozygous mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory