All Phenotypes Isl2<tm1Arbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Isl2^tm1Arbr
targeted mutation 1, Sylvia Arber
MGI:2447837

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nrg1^tm1Cbm/Nrg1^tm3Cbm Isl2^tm1Arbr/Isl2⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:3723120
cn2	Mnx1^tm4(cre)Tmj/Mnx1⁺ Isl2^tm1Arbr/Isl2⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3583819

Allelic Composition	Nrg1^tm1Cbm/Nrg1^tm3Cbm Isl2^tm1Arbr/Isl2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2^tm1Arbr mutation (1 available); any Isl2 mutation (28 available)
Nrg1^tm1Cbm mutation (0 available); any Nrg1 mutation (54 available)
Nrg1^tm3Cbm mutation (0 available); any Nrg1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:69623 )

• ~90% of mice die at birth, with phenotype similar to Nrg1^tm1Cbm homozygous embryos

nervous system

absent Schwann cells ( J:69623 )

• Schwann cells are absent from intramuscular motor axons between E13.5-E16.5

abnormal nervous system development ( J:69623 )

abnormal motor neuron morphology ( J:69623 )

• motor neurons are defasciculated and disorganized

abnormal motor neuron innervation pattern ( J:69623 )

• in developing muscle, motor axons largely retract by birth; by E18.5, motor axons and terminals are absent

abnormal neuromuscular synapse morphology ( J:69623 )

• at diaphragm synapses, band of acetylcholine receptors (AChRs) is wider (17.5% of muscle length) than in wild-type muscle (7% of muscle length)

Allelic Composition	Mnx1^tm4(cre)Tmj/Mnx1⁺ Isl2^tm1Arbr/Isl2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2^tm1Arbr mutation (1 available); any Isl2 mutation (28 available)
Mnx1^tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron morphology ( J:69623 , J:76364 )

• mice lack motor neurons when examined from E12 to E16.9 (J:69623)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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