Phenotypes associated with this allele

• Allele Symbol: Gclm^tm1Tdal
• Allele Name: targeted mutation 1, Timothy P Dalton
• Allele ID: MGI:2447852
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gclm^tm1Tdal/Gclm^tm1Tdal	B6.129-Gclm^tm1Tdal	MGI:5519057
hm2	Gclm^tm1Tdal/Gclm^tm1Tdal	involves: 129 * C57BL/6J	MGI:3757552

Genotype
MGI:5519057

hm1

• Allelic Composition: Gclm^tm1Tdal/Gclm^tm1Tdal
• Genetic Background: B6.129-Gclm^tm1Tdal

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal cingulate gyrus morphology ( J:197430 )

• fewer parvalbumin (PV) labeled cells in the anterior cingulate cortex by 180 days of age

• higher proportion of PV cells are surrounded by aggrecan-enriched perineuronal nets

abnormal nervous system electrophysiology ( J:197430 )

• induced rhythmic neuronal beta and gamma oscillations are weaker at 180 days than they are in controls

cellular

oxidative stress ( J:197430 )

• increased oxidative stress in the anterior cingulate cortex at 90 days of age

• aggrecan-enriched perineuronal nets are reduced by oxidative stress

• sensitivity to oxidative stress is greater at 20 days of age before formation of aggrecan-enriched perineuronal nets

Genotype
MGI:3757552

hm2

• Allelic Composition: Gclm^tm1Tdal/Gclm^tm1Tdal
• Genetic Background: involves: 129 * C57BL/6J

homeostasis/metabolism

decreased cysteine level ( J:80927 )

• kidney and pancreas cysteine levels are decreased to 9% and 35%, respectively, of wild-type levels

decreased circulating cysteine level ( J:80927 )

• cysteine plasma levels are decreased 40% compared to wild-type levels

cellular

increased cellular sensitivity to hydrogen peroxide ( J:80927 )

• mouse fetal fibroblast cells are 10-fold more sensitive to hydrogen peroxide treatment