Phenotypes associated with this allele

• Allele Symbol: Igf2r^tm1.1Rlj
• Allele Name: targeted mutation 1.1, Randy L Jirtle
• Allele ID: MGI:2447858
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igf2r^tm1.1Rlj/Igf2r^+	involves: 129/Sv * BALB/cJ * C57BL/6J	MGI:3795370

Genotype
MGI:3795370

ht1

• Allelic Composition: Igf2r^tm1.1Rlj/Igf2r⁺
• Genetic Background: involves: 129/Sv * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:80932 )

• no mutant mice are recovered at birth

embryo

increased embryo size ( J:80932 )

• mutants are 36% larger than wild-type at E18.5

enlarged placenta ( J:80932 )

• placentas of mutant embryos are 30% larger than corresponding wild-type organs of E18.5 embryos

growth/size/body

increased embryo size ( J:80932 )

• mutants are 36% larger than wild-type at E18.5

respiratory system

abnormal lung development ( J:80932 )

• at E18.5, lungs are poorly developed

impaired branching involved in preterminal bronchiole morphogenesis ( J:80932 )

• low frequency of bronchiole structures is observed

limbs/digits/tail

short tail ( J:80932 )

• tails of embryos are shorter and blunter than wild-type

kinked tail ( J:80932 )

• some mutant tails possess a characteristic kink in the tip

cellular

genetic imprinting ( J:80932 )

• the paternally-inherited Igf2r allele is normallly silenced through genomic imprinting so embryos inheriting the Igf2r-null allele maternally are functionally homozygous knockouts