Phenotypes associated with this allele

• Allele Symbol: Rce1^tm2Kim
• Allele Name: targeted mutation 2, Edward Kim
• Allele ID: MGI:2447870
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rce1^tm2Kim/Rce1^tm2.1Kim Tg(Myh6-cre)2182Mds/0	involves: C57BL/6	MGI:3032514
cn2	Rce1^tm2Kim/Rce1^tm2Kim Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:3032513
cn3	Rce1^tm2Kim/Rce1^tm1Visu Tg(Six3-cre)69Frty/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:6382984

Genotype
MGI:3032514

cn1

• Allelic Composition: Rce1^tm2Kim/Rce1^tm2.1Kim; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87958 )

• some mice died 3 to 5 months after birth

• 50% had died by 7 months of age

• 70% had died by 10 months of age

behavior/neurological

lethargy ( J:87958 )

• mice were listless several weeks prior to death

cardiovascular system

thin myocardium ( J:87958 )

• thin and dystrophic left ventricular musculature

• increased collagen between ventricular myoctes

enlarged heart ( J:87958 )

• histological analysis revealed dilation of all four chambers

dilated heart left ventricle ( J:87958 )

dilated heart right ventricle ( J:87958 )

dilated cardiomyopathy ( J:87958 )

homeostasis/metabolism

abnormal atrial thrombosis ( J:87958 )

• organized thrombi occasionally noted in left atria

edema ( J:87958 )

• pleural and peritoneal fluid accumulation observed upon autopsy

muscle

thin myocardium ( J:87958 )

• thin and dystrophic left ventricular musculature

• increased collagen between ventricular myoctes

dilated cardiomyopathy ( J:87958 )

integument

disheveled coat ( J:87958 )

• observed several weeks prior to death

growth/size/body

enlarged heart ( J:87958 )

• histological analysis revealed dilation of all four chambers

Genotype
MGI:3032513

cn2

• Allelic Composition: Rce1^tm2Kim/Rce1^tm2Kim; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

liver/biliary system

liver/biliary system phenotype ( J:87958 )

N • normal histological appearance of the liver

N • normal serum transaminase levels

Genotype
MGI:6382984

cn3

• Allelic Composition: Rce1^tm2Kim/Rce1^tm1Visu; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

vision/eye

vision/eye phenotype ( J:171900 )

N • normal retinal ganglion and outer and inner nuclear layers at age P8

N • normal retinal ganglion and inner nuclear layers up to age 1 year

N • normal development and survival of horizontal, amacrine and ganglion cells at age P30

thin retina outer nuclear layer ( J:171900 )

• at age P16

• normal at age P8

retina outer nuclear layer degeneration ( J:171900 )

• at age P16

• normal at age P8

decreased a-wave amplitude ( J:171900 )

• with scotopic and photopic ERG at age P14 and P35

decreased b-wave amplitude ( J:171900 )

• with scotopic and photopic ERG at age P14 and P35