All Phenotypes Ccr8<tm1Lira> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccr8^tm1Lira
targeted mutation 1, Sergio A Lira
MGI:2447888

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccr8^tm1Lira/Ccr8^tm1Lira	involves: 129S/SvEv * C57BL/6	MGI:3700957

Allelic Composition	Ccr8^tm1Lira/Ccr8^tm1Lira
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr8^tm1Lira mutation (0 available); any Ccr8 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:118417 )

• mean onset of EAE in response to pertussis toxin treatment is delayed ~2 days in mutants compared to wild-type; incidence is comparable but severity is reduced

• detectable leukocyte infiltration to the CNS is delayed compared to wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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