Phenotypes associated with this allele

• Allele Symbol: Hld
• Allele Name: hippocampal lamination defect
• Allele ID: MGI:2447987
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hld/Hld	either: (involves: BALB/cByJ) or (involves: BALB/cJ)	MGI:4415073
hm2	Hld/Hld	involves: BALB/cJ	MGI:5617539

Genotype
MGI:4415073

hm1

• Allelic Composition: Hld/Hld
• Genetic Background: either: (involves: BALB/cByJ) or (involves: BALB/cJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal migration ( J:13989 )

abnormal hippocampus morphology ( J:13989 )

abnormal hippocampus CA3 region morphology ( J:12029 )

• there is abnormal lamination of this cell layer resulting in superficial early generated neurons and deep late-generated neurons

abnormal hippocampal mossy fiber morphology ( J:12029 )

abnormal hippocampus layer morphology ( J:13989 )

• Background Sensitivity: the anomaly is also seen in BALB/cByJ, F1 mice involving BALB sublines noted, and some CXB RI lines; C57BL/6J is considered wild-type for this feature

• this is secondary to a defect in neuronal migration

ectopic hippocampus pyramidal cells ( J:12029 )

• located below the intrapyramidal layer; some of the ectopic cells have short, fine-caliber dendritic branches arising near the points of contact of the intrapyramidal mossy fibers

abnormal dendrite morphology ( J:12029 )

• abnormally positioned by being late-generated

• cell bodies are located below the intrapyramidal mossy fiber layer

cellular

abnormal neuronal migration ( J:13989 )

Genotype
MGI:5617539

hm2

• Allelic Composition: Hld/Hld
• Genetic Background: involves: BALB/cJ

nervous system

abnormal hippocampal mossy fiber morphology ( J:5486 )

• mossy fibers form a substantial intrapyramidal synaptic field rather than the expected infrapyramidal synaptic field