Phenotypes associated with this allele

• Allele Symbol: Rpl38^Rbt
• Allele Name: Rabo torcido
• Allele ID: MGI:2447994
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rpl38^Rbt/Rpl38^Rbt	involves: C57BL/6J	MGI:3715246
ht2	Rpl38^Rbt/Rpl38^+	involves: C3H * C57BL/6J	MGI:3715245
ht3	Rpl38^Rbt/Rpl38^+	involves: C57BL/6J	MGI:3715242
ht4	Rpl38^Rbt/Rpl38^+	involves: C57BL/6J * DBA	MGI:3715243
ht5	Rpl38^Rbt/Rpl38^+	involves: C57BL/6J * NMRI	MGI:3715236

Genotype
MGI:3715246

hm1

• Allelic Composition: Rpl38^Rbt/Rpl38^Rbt
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:37422 )

• die shortly after implantation

Genotype
MGI:3715245

ht2

• Allelic Composition: Rpl38^Rbt/Rpl38⁺
• Genetic Background: involves: C3H * C57BL/6J

mortality/aging

prenatal lethality, incomplete penetrance ( J:37422 )

• Background Sensitivity: crosses of heterozygotes with C3H mice result in only 3% instead of the expected 50% of heterozygous pups that are born, compared to 46%, 16% and 9% when heterozygotes are crossed with NMRI, C57BL/6J, and DBA mice, respectively

Genotype
MGI:3715242

ht3

• Allelic Composition: Rpl38^Rbt/Rpl38⁺
• Genetic Background: involves: C57BL/6J

mortality/aging

prenatal lethality, incomplete penetrance ( J:37422 )

• Background Sensitivity: crosses of heterozygotes with C57BL/6J mice result in only 16% instead of the expected 50% of heterozygous pups that are born, compared to 46%, 9% and 3% when heterozygotes are crossed with NMRI, DBA, and C3H mice, respectively

Genotype
MGI:3715243

ht4

• Allelic Composition: Rpl38^Rbt/Rpl38⁺
• Genetic Background: involves: C57BL/6J * DBA

mortality/aging

prenatal lethality, complete penetrance ( J:37422 )

• Background Sensitivity: crosses of heterozygotes with DBA mice result in only 9% instead of the expected 50% of heterozygous pups that are born, compared to 46%, 16% and 3% when heterozygotes are crossed with NMRI, C57BL/6J, and C3H mice, respectively

Genotype
MGI:3715236

ht5

• Allelic Composition: Rpl38^Rbt/Rpl38⁺
• Genetic Background: involves: C57BL/6J * NMRI

Skeletal analysis of Rbt/+ and wild-type newborn mice.

mortality/aging

mortality/aging ( J:37422 )

N • Background Sensitivity: crosses of heterozygotes with NMRI mice result in 46% of the expected 50% of born heterozygous pups, unlike when mutants are crossed with C57BL/6J, DBA or C3H, in which only 16%, 9%, and 3%, respectively, of pups born are heterozygotes

growth/size/body

decreased body size ( J:37422 )

decreased body weight ( J:37422 )

postnatal growth retardation ( J:37422 )

• mutants are retarded at least 24 hours in development

craniofacial

abnormal cranium morphology ( J:37422 )

• occasionally see abnormalities of the skull

limbs/digits/tail

caudal vertebral transformation ( J:37422 )

• the first caudal vertebrae is transformed into the 4th sacral vertebrae

short tail ( J:37422 )

kinked tail ( J:37422 )

skeleton

abnormal cranium morphology ( J:37422 )

• occasionally see abnormalities of the skull

asymmetric sternocostal joints ( J:37422 )

• 92% of mutants show a sternum in which the attachment site of the ribs is asymmetric

abnormal rib morphology ( J:37422 )

increased rib number ( J:37422 )

• 15 ribs instead of 13

• all heterozygotes have 8 instead of 7 vertebrosternal ribs

abnormal cervical vertebrae morphology ( J:37422 )

• 92% develop a minute or extensive rib anlage on one or both processus transversus of the 7th cervical vertebrae partially fused to the first thoracic vertebrae rib with our without the generation of a head of a rib; the costosternal junction never forms indicating that posterior transformation of C7 is incomplete

abnormal cervical atlas morphology ( J:37422 )

• sometimes observe two ossification centers of the anterior arch of the atlas

cervical vertebral fusion ( J:37422 )

• occasionally observe partial fusion of the atlas and axis

abnormal vertebral arch morphology ( J:37422 )

• occasionally observe dyssymphysis of neural arches, most prominently the C1-Th1

abnormal vertebral lamina morphology ( J:37422 )

• occasionally see fusions of laminae

abnormal vertebral pedicle morphology ( J:37422 )

• occasionally see fusions or lack of pedicles

abnormal vertebral spinous process morphology ( J:37422 )

• in 84% of mutants, the pronounced spinous process is not sufficiently developed

abnormal vertebral transverse process morphology ( J:37422 )

• 4-5 transverse processes fuse to form the sacral bone compared to 3-4 in wild-type

vertebral transformation ( J:37422 )

• anterior and posterior homeotic transformations along the complete anteroposterior axis

caudal vertebral transformation ( J:37422 )

• the first caudal vertebrae is transformed into the 4th sacral vertebrae

lumbar vertebral transformation ( J:37422 )

• the first lumbar vertebrae is transformed into a thoracic vertebrae, resulting in 14 thoracic vertebrae

sacral vertebral transformation ( J:37422 )

• the first sacral vertebrae is transformed into the 6th lumbar vertebrae