Phenotypes associated with this allele

• Allele Symbol: Tsil^{Tg(Myc)12ALvn}
• Allele Name: transgene insertion 12A, Agnes Lavenu
• Allele ID: MGI:2447997
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tsil^Tg(Myc)12ALvn/Tsil^Tg(Myc)12ALvn	involves: C57BL/6 * SJL/J	MGI:2655289
ht2	Tsil^Tg(Myc)12ALvn/Tsil^+	involves: C57BL/6 * SJL/J	MGI:2655290

Genotype
MGI:2655289

hm1

• Allelic Composition: Tsil^{Tg(Myc)12ALvn}/Tsil^{Tg(Myc)12ALvn}
• Genetic Background: involves: C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:33857 )

• morbidity observed as soon as 1 month of age with death between 2 and 4 months of age

immune system

increased double-positive T cell number ( J:33857 )

• increased thymic CD4⁺ CD8⁺ population, however mice became moribound and died prior to tumor development

hematopoietic system

increased double-positive T cell number ( J:33857 )

• increased thymic CD4⁺ CD8⁺ population, however mice became moribound and died prior to tumor development

Genotype
MGI:2655290

ht2

• Allelic Composition: Tsil^{Tg(Myc)12ALvn}/Tsil⁺
• Genetic Background: involves: C57BL/6 * SJL/J

neoplasm

increased lymphoma incidence ( J:33857 )

• approximately 50% develop T cell lymphoma between 2 and 5 months of age