Phenotypes associated with this allele

• Allele Symbol: Bmp3^tm1Kml
• Allele Name: targeted mutation 1, Karen M Lyons
• Allele ID: MGI:2448071
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp3^tm1Kml/Bmp3^tm1Kml	involves: 129S4/SvJae * CD-1	MGI:2658716

Genotype
MGI:2658716

hm1

• Allelic Composition: Bmp3^tm1Kml/Bmp3^tm1Kml
• Genetic Background: involves: 129S4/SvJae * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:75187 )

N • homozygous null embryos and newborns did not display a skeletal phenotype

N • TRAP staining revealed no differences in the numbers of osteoclasts or in numbers of osteoblasts per area of trabecular bone relative to wild-type

N • fluorochrome labeling revealed normal mineral apposition rates relative to wild-type

increased bone mineral density of femur ( J:75187 )

• in adult mutant mice, the size and shape of femurs appeared normal; however, radiography revealed an increased bone density in femurs from 5-6-week-old homozygotes relative to wild-type

• histomorphometry confirmed that homozygotes had increased trabecular metaphyseal bone density

increased trabecular bone volume ( J:75187 )

• in homozygotes, total trabecular bone volume was twice that of wild-type, despite considerable variation among individual mice of each genotype