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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrg1tm1Fej
targeted mutation 1, Frank E Jones
MGI:2448075
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrg1tm1Fej/Nrg1tm1Fej involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:3530443
cn2
 		Nrg1tm1Fej/Nrg1tm1Fej
Neurod6tm1(cre)Kan/? 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3835559
cn3
 		Nrg1tm1Fej/Nrg1tm1Fej
Emx1tm1(cre)Krj/? 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:3835560
cn4
 		Nrg1tm1Fej/Nrg1tm1Fej
Tg(Nes-cre)1Kln/? 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3835561
cn5
 		Nrg1tm1Fej/Nrg1tm1Fej
Tg(Camk2a-cre)#Kln/? 		involves: 129P2/OlaHsd * CBA/J MGI:3835558


Genotype
MGI:3530443
hm1
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:81107 )
• a decrease in alveolar development in pregnant mice was observed at days 12.5-17 dpc, with the alveoli remaining condensed, suggesting a lactation defect
• at parturition, alveoli appreared distended compared to controls and the luminal epithelial cells appeared flat in shape compared to the cuboidal shape in controls, although secretory activity was apparent
• by 6 days postpartum, mammary gland morphology appeared similar to controls, indicating that the impairment of alveolar development was transient
• despite these defects, dams were able to support lactate and support litters

reproductive system
abnormal mammary gland growth during pregnancy ( J:81107 )
• a decrease in alveolar development in pregnant mice was observed at days 12.5-17 dpc, with the alveoli remaining condensed, suggesting a lactation defect
• at parturition, alveoli appreared distended compared to controls and the luminal epithelial cells appeared flat in shape compared to the cuboidal shape in controls, although secretory activity was apparent
• by 6 days postpartum, mammary gland morphology appeared similar to controls, indicating that the impairment of alveolar development was transient
• despite these defects, dams were able to support lactate and support litters

integument
abnormal mammary gland growth during pregnancy ( J:81107 )
• a decrease in alveolar development in pregnant mice was observed at days 12.5-17 dpc, with the alveoli remaining condensed, suggesting a lactation defect
• at parturition, alveoli appreared distended compared to controls and the luminal epithelial cells appeared flat in shape compared to the cuboidal shape in controls, although secretory activity was apparent
• by 6 days postpartum, mammary gland morphology appeared similar to controls, indicating that the impairment of alveolar development was transient
• despite these defects, dams were able to support lactate and support litters




Genotype
MGI:3835559
cn2
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Neurod6tm1(cre)Kan/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• fully viable and comparable to wild-type controls
• cortex and hippocampus appear normal morphologically and immunohistochemically




Genotype
MGI:3835560
cn3
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Emx1tm1(cre)Krj/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• forebrain fully myelinated at 4 months of age
• no morphological or biochemical differences from wild-type controls




Genotype
MGI:3835561
cn4
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Tg(Nes-cre)1Kln/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (54 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• brain morphology normal at birth
abnormal Schwann cell morphology ( J:145464 )
• spinal cord ventral root Schwann cell development is blocked




Genotype
MGI:3835558
cn5
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Tg(Camk2a-cre)#Kln/?
Genetic
Background		 involves: 129P2/OlaHsd * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (54 available)
Tg(Camk2a-cre)#Kln mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• no developmental abnormalities in the cortex, hippocampus, or subcortical white matter
• no demyelination at older ages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory