All Phenotypes Nrg1<tm2Zhou> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nrg1^tm2Zhou
targeted mutation 2, Mingdong Zhou
MGI:2448078

Summary

2 genotypes

Allelic Composition	Nrg1^tm2Zhou/Nrg1^tm2Zhou
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1^tm2Zhou mutation (0 available); any Nrg1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• die at E10.5-E11.5

cardiovascular system

abnormal heart morphology ( J:81106 )

• cardiac defects observed

Allelic Composition	Nrg1^tm2Zhou/Nrg1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1^tm2Zhou mutation (0 available); any Nrg1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:81106 )

• animals are significantly more active than controls in an open field test and in a four arm-cross maze test

• treatment of mice with 1mg/kg clozapine reversed the phenotype

nervous system

abnormal prepulse inhibition ( J:81106 )

• impairment was seen, while normal acoustic startle response was also observed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:81106

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24