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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Car9tm1Spas
targeted mutation 1, Silvia Pastorekova
MGI:2448129
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Car9tm1Spas/Car9tm1Spas B6.129P2-Car9tm1Spas MGI:3784568
hm2
 		Car9tm1Spas/Car9tm1Spas involves: 129P2/OlaHsd MGI:3037432
cx3
 		Car2n/Car2n
Car9tm1Spas/Car9tm1Spas 		involves: C57BL/6J * DBA/2J MGI:3784571
cx4
 		Car2n/Car2n
Car9tm1Spas/Car9+ 		involves: C57BL/6J * DBA/2J MGI:3784572


Genotype
MGI:3784568
hm1
Allelic
Composition		 Car9tm1Spas/Car9tm1Spas
Genetic
Background		 B6.129P2-Car9tm1Spas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car9tm1Spas mutation (1 available); any Car9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Morphological changes in the stomach and intestine of Car2n/Car2n and Car9tm1Spas/Car9tm1Spas mice

digestive/alimentary system
abnormal small intestine crypts of Lieberkuhn morphology ( J:102478 )
• a few mice have enlarged small intestinal crypts
gastric gland atrophy ( J:102478 )
• 40% of mutants have mild glandular atrophy
stomach epithelial hyperplasia ( J:102478 )
• gastric pit-cell hyperplasia of the stomach in all mutants, with 60% exhibiting mild and 40% moderate hyperplasia
abnormal digestive system physiology ( J:102478 )
• the net basal bicarbonate secretion and the net bicarbonate output during prostaglandin E2 (PGE2) stimulation are significantly increased in mutants

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:102478 )
• a few mice have enlarged small intestinal crypts
gastric gland atrophy ( J:102478 )
• 40% of mutants have mild glandular atrophy




Genotype
MGI:3037432
hm2
Allelic
Composition		 Car9tm1Spas/Car9tm1Spas
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car9tm1Spas mutation (1 available); any Car9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:80329 )
N
• homozygous mutant mice display normal gastric acid secretion and appropriately acidic pH as well as normal systemic acid-base status and plasma electrolyte values
duodenal lesions ( J:80329 )
• homozygous mutant mice display rare cases of duodenal adenoma
abnormal stomach mucosa morphology ( J:80329 )
• newborn mutant mice display mild alterations in the thickness of the gastric mucosa as early as day P0.5
• deregulated proliferation affects the mucosa without any evident morphologic alterations of the cells and without any significant changes in cell death
abnormal gastric parietal cell morphology ( J:80329 )
• the hyperplastic mucosa contains an increased number of parietal cells, but their proportion is significantly lower than in wild-type controls
stomach epithelial hyperplasia ( J:80329 )
• homozygous mutant mice are viable and fertile; no other phenotypic alterations are observed in other tissues, except for rare cases of duodenal adenoma

endocrine/exocrine glands
abnormal gastric parietal cell morphology ( J:80329 )
• the hyperplastic mucosa contains an increased number of parietal cells, but their proportion is significantly lower than in wild-type controls




Genotype
MGI:3784571
cx3
Allelic
Composition		 Car2n/Car2n
Car9tm1Spas/Car9tm1Spas
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (21 available)
Car9tm1Spas mutation (1 available); any Car9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:102478 )
• only one of 10 expected mice is born

digestive/alimentary system
abnormal small intestine crypts of Lieberkuhn morphology ( J:102478 )
• enlarged crypts of the small intestine
stomach epithelial hyperplasia ( J:102478 )
• mild pit-cell hyperplasia of the stomach

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:102478 )
• enlarged crypts of the small intestine




Genotype
MGI:3784572
cx4
Allelic
Composition		 Car2n/Car2n
Car9tm1Spas/Car9+
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (21 available)
Car9tm1Spas mutation (1 available); any Car9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal duodenum morphology ( J:102478 )
• some mutants exhibit intraepithelial lymphocytes in the duodenum
gastric gland atrophy ( J:102478 )
• 13% of mutants have mild glandular atrophy
stomach epithelial hyperplasia ( J:102478 )
• 50% of mutants have mild pit-cell hyperplasia
gastric cyst ( J:102478 )
• 50% of mutants have gastric cysts
abnormal digestive system physiology ( J:102478 )
• bicarbonate secretory response of the duodenum to prostaglandin E2 (PGE2) is completely absent in mutants

endocrine/exocrine glands
gastric gland atrophy ( J:102478 )
• 13% of mutants have mild glandular atrophy

growth/size/body
gastric cyst ( J:102478 )
• 50% of mutants have gastric cysts




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory