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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nr6a1tm2Coo
targeted mutation 2, Austin J Cooney
MGI:2448158
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nr6a1tm2Coo/Nr6a1tm2Coo involves: 129S7/SvEvBrd * C57BL/6 MGI:3818516


Genotype
MGI:3818516
hm1
Allelic
Composition
Nr6a1tm2Coo/Nr6a1tm2Coo
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr6a1tm2Coo mutation (0 available); any Nr6a1 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• normal ratio of homozygotes at E8.5-9.5
• no homozygotes after E10.5

embryo
• embryos normal to E8
• do not undergo turning
• anterior neural tube fails to close although it continues to grow
• large invagination of neural epithelium within the primitive streak at E8.5
• no more than 13 somites form
• reduced trunk and posterior structures
• tail bud protrudes from the yolk sac at E9.5
• protrusion of tissue at the base of the allantois starting at E8.75
• often fails to attach to the chorion
• often unattached to allantois
• allantois often fails to attach to the chorion

nervous system
• anterior neural tube fails to close although it continues to grow

digestive/alimentary system
• hindgut fails to form

cardiovascular system
• pericardium is often dilated

limbs/digits/tail
• tail bud protrudes from the yolk sac at E9.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory