Phenotypes associated with this allele

• Allele Symbol: Cuzd1^tm1Ljm
• Allele Name: targeted mutation 1, Louis J Muglia
• Allele ID: MGI:2448160
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cuzd1^tm1Ljm/Cuzd1^tm1Ljm	involves: 129S6/SvEvTac * Black Swiss	MGI:3695289

Genotype
MGI:3695289

hm1

• Allelic Composition: Cuzd1^tm1Ljm/Cuzd1^tm1Ljm
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:80980 )

• survival after induction of pancreatitis is reduced to 53%

endocrine/exocrine glands

increased susceptibility to induced pancreatitis ( J:80980 )

• increased susceptibility to induced pancreatitis

• when induced by cerulein or a choline deficient and ethionine containing diet

• greater edema is seen resulting in wider separation between pancreatic lobules and acini are disrupted

• increased pancreatic weight

• increased acinar necrosis and higher levels of apoptosis elevated serum levels of amylase and lipase increased acinar necrosis and higher levels of apoptosis

• elevated serum levels of amylase and lipase

• increase in trypsin activation peptide and trypsin activity is less than in controls

immune system

increased susceptibility to induced pancreatitis ( J:80980 )

• increased susceptibility to induced pancreatitis

• when induced by cerulein or a choline deficient and ethionine containing diet

• greater edema is seen resulting in wider separation between pancreatic lobules and acini are disrupted

• increased pancreatic weight

• increased acinar necrosis and higher levels of apoptosis elevated serum levels of amylase and lipase increased acinar necrosis and higher levels of apoptosis

• elevated serum levels of amylase and lipase

• increase in trypsin activation peptide and trypsin activity is less than in controls