All Phenotypes Ccnd3<tm1Pisc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccnd3^tm1Pisc
targeted mutation 1, Piotr Sicinski
MGI:2448172

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc	Not Specified	MGI:3036220
cn2	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Rb1^tm2Brn/Rb1^tm2Brn Tg(Mx1-cre)1Cgn/0	involves: 129 * C57BL/6 * CBA	MGI:5468652
cn3	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Rb1^tm2Brn/Rb1^tm2Brn Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJaeSor * C57BL/6 * CBA	MGI:5468653
cx4	Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Ccnd2^tm1Wbg/Ccnd2^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3514155
cx5	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Rag2^tm1Fwa/Rag2^tm1Fwa	involves: 129S/SvEv	MGI:3819979
cx6	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas	MGI:3819978
cx7	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf	involves: 129S4/SvJaeSor	MGI:5468651
cx8	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Tg(Lck)4220Rmp/0	involves: C57BL/6J * DBA/2	MGI:3036302
cx9	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc	Not Specified	MGI:3036179
cx10	Ccnd2^tm1Wbg/Ccnd2^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc	Not Specified	MGI:3036215

Allelic Composition	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell proliferation ( J:192031 )

• of pre-B cells

decreased T cell proliferation ( J:88120 , J:192031 )

• cytokine-driven expansion of DN-4 immature single-positive T lymphocytes is impaired (J:88120)

• of pro- and pre-T cells (J:192031)

small thymus ( J:192031 )

thymus hypoplasia ( J:88120 , J:192031 )

• at 5 weeks mice have severely hypoplastic thymuses (J:88120)

increased double-negative T cell number ( J:88120 )

• fraction of double-negative cells in thymus is increased; however total number of double-negative thymocytes is unchanged compared to wild-type

decreased bone marrow cell number ( J:192031 )

decreased lymphocyte cell number ( J:88120 )

• 4-6 week-old mice have 7-fold fewer thymocytes than wild-type

decreased double-positive T cell number ( J:88120 , J:192031 )

• fraction of double-positive cells in thymus is decreased; total number of double-positive thymocytes is reduced 12-fold (J:88120)

decreased pre-B cell number ( J:192031 )

immune system

decreased B cell proliferation ( J:192031 )

• of pre-B cells

decreased T cell proliferation ( J:88120 , J:192031 )

• cytokine-driven expansion of DN-4 immature single-positive T lymphocytes is impaired (J:88120)

• of pro- and pre-T cells (J:192031)

small thymus ( J:192031 )

thymus hypoplasia ( J:88120 , J:192031 )

• at 5 weeks mice have severely hypoplastic thymuses (J:88120)

increased double-negative T cell number ( J:88120 )

• fraction of double-negative cells in thymus is increased; however total number of double-negative thymocytes is unchanged compared to wild-type

decreased lymphocyte cell number ( J:88120 )

• 4-6 week-old mice have 7-fold fewer thymocytes than wild-type

decreased double-positive T cell number ( J:88120 , J:192031 )

• fraction of double-positive cells in thymus is decreased; total number of double-positive thymocytes is reduced 12-fold (J:88120)

decreased pre-B cell number ( J:192031 )

endocrine/exocrine glands

small thymus ( J:192031 )

thymus hypoplasia ( J:88120 , J:192031 )

• at 5 weeks mice have severely hypoplastic thymuses (J:88120)

cellular

decreased B cell proliferation ( J:192031 )

• of pre-B cells

decreased T cell proliferation ( J:88120 , J:192031 )

• cytokine-driven expansion of DN-4 immature single-positive T lymphocytes is impaired (J:88120)

• of pro- and pre-T cells (J:192031)

Allelic Composition	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Rb1^tm2Brn/Rb1^tm2Brn Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:192031 )

• of pre-T cells as in Ccnd3^tm1Pisc homozygotes

thymus hypoplasia ( J:192031 )

• not as severe as in pIpC-treated mice as in Ccnd3^tm1Pisc homozygotes

decreased double-positive T cell number ( J:192031 )

• as in Ccnd3^tm1Pisc homozygotes

hematopoietic system

decreased T cell proliferation ( J:192031 )

• of pre-T cells as in Ccnd3^tm1Pisc homozygotes

thymus hypoplasia ( J:192031 )

• not as severe as in pIpC-treated mice as in Ccnd3^tm1Pisc homozygotes

decreased double-positive T cell number ( J:192031 )

• as in Ccnd3^tm1Pisc homozygotes

endocrine/exocrine glands

thymus hypoplasia ( J:192031 )

• not as severe as in pIpC-treated mice as in Ccnd3^tm1Pisc homozygotes

cellular

decreased T cell proliferation ( J:192031 )

• of pre-T cells as in Ccnd3^tm1Pisc homozygotes

Allelic Composition	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Rb1^tm2Brn/Rb1^tm2Brn Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (111 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:192031 )

N	• mice exhibit normal numbers of thymocytes, double negative cells, double positive cells and pre-T cell proliferation

Allelic Composition	Ccnd1^tm1Dsn/Ccnd1^tm1Dsn Ccnd2^tm1Wbg/Ccnd2^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Dsn mutation (0 available); any Ccnd1 mutation (22 available)
Ccnd2^tm1Wbg mutation (0 available); any Ccnd2 mutation (25 available)
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:92563 )

• by E15.5 embryos appear pale

• by E16.5 no viable embryos are observed

cardiovascular system

abnormal interventricular septum morphology ( J:92563 )

• embryonic

thin ventricular wall ( J:92563 )

• thinned walls of embryonic heart ventricles, mainly in compact zone

hematopoietic system

abnormal definitive hematopoiesis ( J:92563 )

• total number of fetal liver cells reduced at E14.5

abnormal common myeloid progenitor cell morphology ( J:92563 )

• common myeloid progenitors cells substantially reduced

abnormal lymphopoiesis ( J:92563 )

• common lymphoid progenitors cells reduced by 46 fold

anemia ( J:92563 )

decreased erythrocyte cell number ( J:92563 )

• E14.5 embryos exhibit 8-fold decrease in peripheral blood erythrocytes

abnormal hematopoietic stem cell morphology ( J:92563 )

• impaired ability of hematopoietic stem cells to proliferate

decreased hematopoietic stem cell number ( J:92563 )

• hematopoietic stem cells reduced 5.7 fold in E14.5 liver

homeostasis/metabolism

hydrops fetalis ( J:92563 )

• embryonic

immune system

abnormal lymphopoiesis ( J:92563 )

• common lymphoid progenitors cells reduced by 46 fold

Allelic Composition	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Rag2^tm1Fwa/Rag2^tm1Fwa
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (119 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased T cell proliferation ( J:88120 )

• after injection with anti-CD3epsilon antibodies number of thymocytes increases 60-fold compared to Ccnd3-competent, Rag2 null animals

immune system

increased T cell proliferation ( J:88120 )

• after injection with anti-CD3epsilon antibodies number of thymocytes increases 60-fold compared to Ccnd3-competent, Rag2 null animals

cellular

increased T cell proliferation ( J:88120 )

• after injection with anti-CD3epsilon antibodies number of thymocytes increases 60-fold compared to Ccnd3-competent, Rag2 null animals

Allelic Composition	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:88120 )

• animals die by about 26 weeks

neoplasm

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies with similar kinetics as Trp53-null mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies with similar kinetics as Trp53-null mice

immune system

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies with similar kinetics as Trp53-null mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies with similar kinetics as Trp53-null mice

Allelic Composition	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:192031 )

• of pre-T cells as in Ccnd3^tm1Pisc homozygotes

thymus hypoplasia ( J:192031 )

• not as severe as in Ccnd3^tm1Pisc homozygotes

decreased double-positive T cell number ( J:192031 )

• as in Ccnd3^tm1Pisc homozygotes

hematopoietic system

decreased T cell proliferation ( J:192031 )

• of pre-T cells as in Ccnd3^tm1Pisc homozygotes

thymus hypoplasia ( J:192031 )

• not as severe as in Ccnd3^tm1Pisc homozygotes

decreased double-positive T cell number ( J:192031 )

• as in Ccnd3^tm1Pisc homozygotes

abnormal bone marrow cell physiology ( J:192031 )

• bone marrow progenitor cells transfected with a retrovirus encoding the constitutively active intracellular domain of Notch1 slightly delays development of T cell acute lymphoblastic leukemia in recipient irradiated wild-type mice from the

endocrine/exocrine glands

thymus hypoplasia ( J:192031 )

• not as severe as in Ccnd3^tm1Pisc homozygotes

cellular

decreased T cell proliferation ( J:192031 )

• of pre-T cells as in Ccnd3^tm1Pisc homozygotes

Allelic Composition	Ccnd3^tm1Pisc/Ccnd3^tm1Pisc Tg(Lck)4220Rmp/0
Genetic Background	involves: C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)
Tg(Lck)4220Rmp mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:88120 )

• mice develop T cell tumors and die starting at 13-15 weeks of age with 100% mortality observed by 22 weeks

neoplasm

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies starting at 13-15 weeks

decreased lymphoma incidence ( J:88120 )

• tumor formation is delayed 6-8 weeks compared to Ccnd3-sufficient, Tg(Lck)4220Rmp-expressing animals

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies starting at 13-15 weeks

immune system

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies starting at 13-15 weeks

hematopoietic system

increased T cell derived lymphoma incidence ( J:88120 )

• mice develop T cell malignancies starting at 13-15 weeks

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:80994 )

• while mice were born near the expected frequency, most died within the first day demonstrating impaired suckling

• some mice survived the perinatal period

behavior/neurological

abnormal suckling behavior ( J:80994 )

growth/size/body

decreased body size ( J:80994 )

• mice that survived the perinatal period did not thrive and were much smaller than wild-type littermates in spite of a calorie-rich diet

respiratory system

aspiration ( J:80994 )

• suggestions of acute asphyxiation caused by meconium aspiration syndrome

vision/eye

retina hypoplasia ( J:80994 )

Allelic Composition	Ccnd2^tm1Wbg/Ccnd2^tm1Wbg Ccnd3^tm1Pisc/Ccnd3^tm1Pisc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd2^tm1Wbg mutation (0 available); any Ccnd2 mutation (25 available)
Ccnd3^tm1Pisc mutation (0 available); any Ccnd3 mutation (507 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:80994 )

• fetuses died during late gestation with none surviving past E18.5

hematopoietic system

abnormal erythropoiesis ( J:80994 )

macrocytic anemia ( J:80994 )

low mean erythrocyte cell number ( J:80994 )

• ~4 fold decrease in the number of peripheral red blood cells relative to wild-type

macrocytosis ( J:80994 )

liver/biliary system

abnormal liver development ( J:80994 )

• abnormal fetal liver morphogenesis

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