Phenotypes associated with this allele

• Allele Symbol: Zyx^tm1Mbk
• Allele Name: targeted mutation 1, Mary C Beckerle
• Allele ID: MGI:2448217
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zyx^tm1Mbk/Zyx^tm1Mbk	B6.129X1-Zyx^tm1Mbk	MGI:3623290
hm2	Zyx^tm1Mbk/Zyx^tm1Mbk	involves: 129X1/SvJ * C57BL/6J	MGI:2656100

Genotype
MGI:3623290

hm1

• Allelic Composition: Zyx^tm1Mbk/Zyx^tm1Mbk
• Genetic Background: B6.129X1-Zyx^tm1Mbk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:107919 )

• Zyx-deficient cells do not make robust actin stress fibers when exposed to jasplakinolide

abnormal cell adhesion ( J:107919 )

• Zyx-deficient cells are more adherent than wild-type fibroblasts when plated on a variety of substrates

impaired fibroblast cell migration ( J:107919 )

• fibroblasts from mutant mice do not display integrin-dependent migration like wild-type

increased fibroblast cell migration ( J:107919 )

• primary Zyx-deficient fibroblasts display enhanced migration velocity (32 microns/h) compared to wild-type (18 microns/h)

Genotype
MGI:2656100

hm2

• Allelic Composition: Zyx^tm1Mbk/Zyx^tm1Mbk
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:81007 )

• mice were viable, fertile, and developed normally