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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sall2tm1Ryn
targeted mutation 1, Ryuichi Nishinakamura
MGI:2448237
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sall2tm1Ryn/Sall2tm1Ryn involves: 129P2/OlaHsd * C57BL/6J MGI:3699225
cx2
 		Sall1tm1Ryn/Sall1tm1Ryn
Sall2tm1Ryn/Sall2tm1Ryn 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3699226


Genotype
MGI:3699225
hm1
Allelic
Composition		 Sall2tm1Ryn/Sall2tm1Ryn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall2tm1Ryn mutation (1 available); any Sall2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:81008 )
• homozygotes show no apparent abnormal phenotypes including no abnormalities in the kidneys, limbs, or ears, and no spontaneous tumor formation for more than a year




Genotype
MGI:3699226
cx2
Allelic
Composition		 Sall1tm1Ryn/Sall1tm1Ryn
Sall2tm1Ryn/Sall2tm1Ryn
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1tm1Ryn mutation (2 available); any Sall1 mutation (78 available)
Sall2tm1Ryn mutation (1 available); any Sall2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
abnormal kidney morphology ( J:81008 )
• severity or kidney abnormalities is comparable to that seen in single Sall1 homozygotes
kidney cyst ( J:81008 )
• the remnant kidneys have multiple cysts
small kidney ( J:81008 )
• exhibit reduced kidney size at E12.5
• 41.7% have two small remnant kidneys
absent kidney ( J:81008 )
• 25% have no kidneys or ureters bilaterally
single kidney ( J:81008 )
• 33.3% have unilateral kidney agenesis and hypoplasia on the other side
absent ureter ( J:81008 )
• 25% have no kidneys or ureters bilaterally
impaired branching involved in ureteric bud morphogenesis ( J:81008 )
• exhibit impaired ureteric branching at E12.5

growth/size/body
kidney cyst ( J:81008 )
• the remnant kidneys have multiple cysts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory