Phenotypes associated with this allele

• Allele Symbol: Sall2^tm1Ryn
• Allele Name: targeted mutation 1, Ryuichi Nishinakamura
• Allele ID: MGI:2448237
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sall2^tm1Ryn/Sall2^tm1Ryn	involves: 129P2/OlaHsd * C57BL/6J	MGI:3699225
cx2	Sall1^tm1Ryn/Sall1^tm1Ryn Sall2^tm1Ryn/Sall2^tm1Ryn	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:3699226

Genotype
MGI:3699225

hm1

• Allelic Composition: Sall2^tm1Ryn/Sall2^tm1Ryn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:81008 )

• homozygotes show no apparent abnormal phenotypes including no abnormalities in the kidneys, limbs, or ears, and no spontaneous tumor formation for more than a year

Genotype
MGI:3699226

cx2

• Allelic Composition: Sall1^tm1Ryn/Sall1^tm1Ryn; Sall2^tm1Ryn/Sall2^tm1Ryn
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

mortality/aging

perinatal lethality, complete penetrance ( J:81008 )

• all die perinatally

renal/urinary system

abnormal kidney morphology ( J:81008 )

• severity or kidney abnormalities is comparable to that seen in single Sall1 homozygotes

kidney cyst ( J:81008 )

• the remnant kidneys have multiple cysts

small kidney ( J:81008 )

• exhibit reduced kidney size at E12.5

• 41.7% have two small remnant kidneys

absent kidney ( J:81008 )

• 25% have no kidneys or ureters bilaterally

single kidney ( J:81008 )

• 33.3% have unilateral kidney agenesis and hypoplasia on the other side

absent ureter ( J:81008 )

• 25% have no kidneys or ureters bilaterally

abnormal ureteric bud morphology ( J:81008 )

impaired branching involved in ureteric bud morphogenesis ( J:81008 )

• exhibit impaired ureteric branching at E12.5

growth/size/body

kidney cyst ( J:81008 )

• the remnant kidneys have multiple cysts