All Phenotypes Adam12<tm1Asf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adam12^tm1Asf
targeted mutation 1, Atsuko Sehara-Fujisawa
MGI:2448241

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam12^tm1Asf/Adam12^tm1Asf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3056934
cx2	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3654840
cx3	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam17^tm1Imx/Adam17^tm1Imx Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3056935

Allelic Composition	Adam12^tm1Asf/Adam12^tm1Asf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12^tm1Asf mutation (0 available); any Adam12 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:81009 )

• approximately 30% died before weaning, most within one week of birth

adipose tissue

decreased brown adipose tissue amount ( J:81009 )

• interscapular brown adipose tissue was reduced in about 30% of mutants, however at 8 weeks and in surviving adults, brown adipose tissue was normal sized

• adipose lobes were smaller than in wild-type and exhibited looser condensation of adipocytes at E16.5

muscle

abnormal skeletal muscle morphology ( J:81009 )

• some perinatal and newborn (E17.5-P1) mutants showed impaired formation of neck and interscapular muscles and at 8 weeks some interscapular muscles remained slightly reduced in size

decreased skeletal muscle fiber density ( J:81009 )

• muscle fibers close to adipose tissues were not as tightly packed in some mutants

Allelic Composition	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12^tm1Asf mutation (0 available); any Adam12 mutation (42 available)
Adam15^tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam19^{Gt(Betageo)1Bbl} mutation (1 available); any Adam19 mutation (78 available)
Adam9^tm1Bbl mutation (1 available); any Adam9 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:99649 )

• significantly less (4.6%) than the expected Mendelian ratio of 25% of mutants is seen at birth, however normal numbers are seen at E18.5 although less than 1/3 have a visible heartbeat at this time

cardiovascular system

double outlet right ventricle ( J:99649 )

• both the aorta and pulmonic artery emanate from the right ventricle, a more severe malrotation defect than seen in single homozygous Adam19 mutant mice

ventricular septal defect ( J:99649 )

• exhibit a ventricular septal defect at E18.5

abnormal heart valve morphology ( J:99649 )

abnormal mitral valve morphology ( J:99649 )

• thicker and misshapen mitral valve

thick mitral valve ( J:99649 )

abnormal tricuspid valve morphology ( J:99649 )

• misshapen tricuspid valve

tricuspid valve hyperplasia ( J:99649 )

• hyperplastic tricuspid valve

semilunar valve hyperplasia ( J:99649 )

• hyperplastic semilunar valves

Allelic Composition	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam17^tm1Imx/Adam17^tm1Imx Adam9^tm1Bbl/Adam9^tm1Bbl
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12^tm1Asf mutation (0 available); any Adam12 mutation (42 available)
Adam15^tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam17^tm1Imx mutation (0 available); any Adam17 mutation (64 available)
Adam9^tm1Bbl mutation (1 available); any Adam9 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:88801 )

cardiovascular system

abnormal mitral valve morphology ( J:88801 )

• thickened and misshapen valves

thick mitral valve ( J:88801 )

abnormal tricuspid valve morphology ( J:88801 )

• thickened and misshapen valves

thick tricuspid valve ( J:88801 )

abnormal aortic valve morphology ( J:88801 )

• thickened and misshapen valves

thick aortic valve ( J:88801 )

abnormal pulmonary valve morphology ( J:88801 )

• thickened and misshapen valves

thick pulmonary valve ( J:88801 )

vision/eye

eyelids open at birth ( J:88801 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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