All Phenotypes Adam12<tm1Asf> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adam12^tm1Asf
targeted mutation 1, Atsuko Sehara-Fujisawa
MGI:2448241

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam12^tm1Asf/Adam12^tm1Asf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3056934
cx2	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3654840
cx3	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam17^tm1Imx/Adam17^tm1Imx Adam9^tm1Bbl/Adam9^tm1Bbl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3056935

Allelic Composition	Adam12^tm1Asf/Adam12^tm1Asf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12^tm1Asf mutation (0 available); any Adam12 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:81009 )

• approximately 30% died before weaning, most within one week of birth

adipose tissue

decreased brown adipose tissue amount ( J:81009 )

• interscapular brown adipose tissue was reduced in about 30% of mutants, however at 8 weeks and in surviving adults, brown adipose tissue was normal sized

• adipose lobes were smaller than in wild-type and exhibited looser condensation of adipocytes at E16.5

muscle

abnormal skeletal muscle morphology ( J:81009 )

• some perinatal and newborn (E17.5-P1) mutants showed impaired formation of neck and interscapular muscles and at 8 weeks some interscapular muscles remained slightly reduced in size

decreased skeletal muscle fiber density ( J:81009 )

• muscle fibers close to adipose tissues were not as tightly packed in some mutants

Allelic Composition	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam19^{Gt(Betageo)1Bbl}/Adam19^{Gt(Betageo)1Bbl} Adam9^tm1Bbl/Adam9^tm1Bbl
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12^tm1Asf mutation (0 available); any Adam12 mutation (42 available)
Adam15^tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam19^{Gt(Betageo)1Bbl} mutation (1 available); any Adam19 mutation (78 available)
Adam9^tm1Bbl mutation (1 available); any Adam9 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:99649 )

• significantly less (4.6%) than the expected Mendelian ratio of 25% of mutants is seen at birth, however normal numbers are seen at E18.5 although less than 1/3 have a visible heartbeat at this time

cardiovascular system

double outlet right ventricle ( J:99649 )

• both the aorta and pulmonic artery emanate from the right ventricle, a more severe malrotation defect than seen in single homozygous Adam19 mutant mice

ventricular septal defect ( J:99649 )

• exhibit a ventricular septal defect at E18.5

abnormal heart valve morphology ( J:99649 )

abnormal mitral valve morphology ( J:99649 )

• thicker and misshapen mitral valve

thick mitral valve ( J:99649 )

abnormal tricuspid valve morphology ( J:99649 )

• misshapen tricuspid valve

tricuspid valve hyperplasia ( J:99649 )

• hyperplastic tricuspid valve

semilunar valve hyperplasia ( J:99649 )

• hyperplastic semilunar valves

Allelic Composition	Adam12^tm1Asf/Adam12^tm1Asf Adam15^tm1Bbl/Adam15^tm1Bbl Adam17^tm1Imx/Adam17^tm1Imx Adam9^tm1Bbl/Adam9^tm1Bbl
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam12^tm1Asf mutation (0 available); any Adam12 mutation (42 available)
Adam15^tm1Bbl mutation (0 available); any Adam15 mutation (37 available)
Adam17^tm1Imx mutation (0 available); any Adam17 mutation (64 available)
Adam9^tm1Bbl mutation (1 available); any Adam9 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:88801 )

cardiovascular system

abnormal mitral valve morphology ( J:88801 )

• thickened and misshapen valves

thick mitral valve ( J:88801 )

abnormal tricuspid valve morphology ( J:88801 )

• thickened and misshapen valves

thick tricuspid valve ( J:88801 )

abnormal aortic valve morphology ( J:88801 )

• thickened and misshapen valves

thick aortic valve ( J:88801 )

abnormal pulmonary valve morphology ( J:88801 )

• thickened and misshapen valves

thick pulmonary valve ( J:88801 )

vision/eye

eyelids open at birth ( J:88801 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24