Phenotypes associated with this allele

• Allele Symbol: Ltf^tm1Omc
• Allele Name: targeted mutation 1, Orla M Conneely
• Allele ID: MGI:2448243
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltf^tm1Omc/Ltf^tm1Omc	either: 129S/SvEv or (involves: 129S/SvEv * C57BL/6)	MGI:3581450

Genotype
MGI:3581450

hm1

• Allelic Composition: Ltf^tm1Omc/Ltf^tm1Omc
• Genetic Background: either: 129S/SvEv or (involves: 129S/SvEv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal iron homeostasis ( J:81005 )

• total iron binding capacity reduced

decreased spleen iron level ( J:81005 )

• spleen iron stores are reduced

increased circulating iron level ( J:81005 )

• transferrin saturation was significantly elevated at age 18 days

• on a standard diet, serum iron levels are slightly but significantly elevated

• on a high iron diet, serum iron levels do not differ from controls

increased liver iron level ( J:81005 )

• liver iron stores are increased

hematopoietic system

hematopoietic system phenotype ( J:81005 )

N • erythroid parameters of homozygous mice are unexpectedly normal

decreased spleen iron level ( J:81005 )

• spleen iron stores are reduced

immune system

decreased spleen iron level ( J:81005 )

• spleen iron stores are reduced

liver/biliary system

increased liver iron level ( J:81005 )

• liver iron stores are increased