Analysis Tools
mortality/aging
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• only about 10% of homozygous mice survive beyond weaning
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• 45% of homozygotes die within the first 2 days after birth and another 45% die between 2 and 3 weeks after birth
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nervous system
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• by E14, RGC axons do not extend into the diencephalic wall from the chiasm to form an optic tract: at E16 the optic tract is observed to be absent
(J:110804)
• at E14, no axons are found in the optic tract, but by E17-18 axons can be identified, indicating a delay of ~4 days of RGCs entering the optic tract
(J:110816)
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• at P1, very few fibers extend beyond the optic chiasm
(J:22966)
• at P1, nerve fibers in the optic chiasm are tangled with apparently random turns and projections
(J:22966)
• by E14, RGC axons cross the midline but stop a distance of ~450-500 um lateral to the midline
(J:110804)
• at E16, disorderly axon trajectories within an enlarged optic chiasm are observed; axons have abnormal trajectories and some appear to turn back and cross the midline again
(J:110804)
• distribution of ipsilaterally and contralaterally projecting retinal ganglion cells; both are found in all regions of the retina, whereas in wild-type, ipsilatrally projecting RGCs are restricted to the peripheral part of the ventral temporal retina
(J:110816)
• there is a randomization of RGC axon pathfinding at the optic chiasm, such that there is an ~ equal density of RGC axons in the ipsi- and contrlateral retinas
(J:110816)
• at E15-16 there are no axons that make turns 100-200 um before the midline to grow into the ipsilateral tract; at the location of the turning point, axons are found to have more wavy trajectories and not running in parallel trajectories to one another
(J:110816)
• in 30% of E14-18 embryos, a population of axons with sharp turns and meandering trajectories is observed; after turning, the axons do not project into the ipsilateral tract
(J:110816)
• RGC axons growing into to the contralateral tract exhibit abnormal trajectories; some grow in a wide arc, others grow in a wider arc than normal but are found posteriorly, and the rest which grow along the midline posteriorly before leaving the midline to grow into the contralateral optic tract
(J:110816)
• ipsilateral axons originate from all regions of the retina and take three different paths to enter the ipsilateral optic tract
(J:110816)
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• at E15, the optic chiasm appears more rounded and enlarged compared to control animals
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vision/eye
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• at P1, very few fibers extend beyond the optic chiasm
(J:22966)
• at P1, nerve fibers in the optic chiasm are tangled with apparently random turns and projections
(J:22966)
• by E14, RGC axons cross the midline but stop a distance of ~450-500 um lateral to the midline
(J:110804)
• at E16, disorderly axon trajectories within an enlarged optic chiasm are observed; axons have abnormal trajectories and some appear to turn back and cross the midline again
(J:110804)
• distribution of ipsilaterally and contralaterally projecting retinal ganglion cells; both are found in all regions of the retina, whereas in wild-type, ipsilatrally projecting RGCs are restricted to the peripheral part of the ventral temporal retina
(J:110816)
• there is a randomization of RGC axon pathfinding at the optic chiasm, such that there is an ~ equal density of RGC axons in the ipsi- and contrlateral retinas
(J:110816)
• at E15-16 there are no axons that make turns 100-200 um before the midline to grow into the ipsilateral tract; at the location of the turning point, axons are found to have more wavy trajectories and not running in parallel trajectories to one another
(J:110816)
• in 30% of E14-18 embryos, a population of axons with sharp turns and meandering trajectories is observed; after turning, the axons do not project into the ipsilateral tract
(J:110816)
• RGC axons growing into to the contralateral tract exhibit abnormal trajectories; some grow in a wide arc, others grow in a wider arc than normal but are found posteriorly, and the rest which grow along the midline posteriorly before leaving the midline to grow into the contralateral optic tract
(J:110816)
• ipsilateral axons originate from all regions of the retina and take three different paths to enter the ipsilateral optic tract
(J:110816)
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• at E15, the optic chiasm appears more rounded and enlarged compared to control animals
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growth/size/body
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• surviving pups show a reduced rate of weight gain over the first month after birth, such that weight is 55% of wild-type littermates at day 15; by 3 months of age, body weigh is 90% of control
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