Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-ERBB3)1Slg
• Allele Name: transgene insertion 1, Stanton L Gerson
• Allele ID: MGI:2448360
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(MMTV-ERBB3)1Slg/0 Tg(MMTVneu)202Mul/0	involves: FVB	MGI:2654499
tg2	Tg(MMTV-ERBB3)1Slg/0	involves: FVB	MGI:2654498

Genotype
MGI:2654499

cx1

• Allelic Composition: Tg(MMTV-ERBB3)1Slg/0; Tg(MMTVneu)202Mul/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:80974 )

• 18 of 23 mice develop mammary tumors

increased incidence of tumors by chemical induction ( J:80974 )

• increased incidence (45.5%) of MNU-induced lung adenocarcinomas compared to 16% in MNU treated controls

• latency of induced tumor development is shorter than in wild-type controls or single hemizygous Tg(MMTV-ERBB3)1Slg mice

increased lung adenocarcinoma incidence ( J:80974 )

• increased incidence (30.4%) of spontaneous lung adenocarcinomas

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:80974 )

• increased incidence (45.5%) of MNU-induced lung adenocarcinomas compared to 16% in MNU treated controls

• latency of induced tumor development is shorter than in wild-type controls or single hemizygous Tg(MMTV-ERBB3)1Slg mice

respiratory system

increased lung adenocarcinoma incidence ( J:80974 )

• increased incidence (30.4%) of spontaneous lung adenocarcinomas

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:80974 )

• 18 of 23 mice develop mammary tumors

integument

increased mammary gland tumor incidence ( J:80974 )

• 18 of 23 mice develop mammary tumors

Genotype
MGI:2654498

tg2

• Allelic Composition: Tg(MMTV-ERBB3)1Slg/0
• Genetic Background: involves: FVB

neoplasm

increased incidence of tumors by chemical induction ( J:80974 )

• increased incidence (51.7%) of MNU-induced lung adenocarcinomas compared to 16% of controls

increased lung adenocarcinoma incidence ( J:80974 )

• increase in incidence (27.5%) of spontaneous lung adenocarcinomas; no mammary gland tumors are observed

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:80974 )

• increased incidence (51.7%) of MNU-induced lung adenocarcinomas compared to 16% of controls

respiratory system

increased lung adenocarcinoma incidence ( J:80974 )

• increase in incidence (27.5%) of spontaneous lung adenocarcinomas; no mammary gland tumors are observed