mortality/aging
• embryos die between E4.5 and E6.5
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embryo
• embryos implant into the uterus but fail to develop beyond the early egg cylinder stage
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• at E6.5, egg cylinders appear severely attenuated, are often fragmented, and lack an organized two-layered cell structure
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• egg cylinders are severely attenuated at E6.5
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• no amniotic folds are obseved at E6.5
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• no ectoplacental cavities are observed at E6.5
• however, mutant embryos appear to develop normal ectoplacental cones and extraembryonic membranes and make good contact with the uterus
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• no proamniotic cavities are observed at E6.5
• however, embryos appear to develop normal ectoplacental cones and extraembryonic membranes and make good contact with the uterus
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reproductive system
• some empty deciduas are noted at E6.5
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