mortality/aging
• embryos die between E4.5 and E6.5
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embryo
• mutant embryos implant into the uterus but fail to develop beyond the early egg cylinder stage
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• at E6.5, mutant egg cylinders appear severely attenuated, are often fragmented and lack an organized two-layered cell structure
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• no amniotic folds are obseved at E6.5
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• at E6.5, ectoplacental cavities are not observed
• however, mutant embryos appear to develop normal ectoplacental cones and extraembryonic membranes and make good contact with the uterus
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• at E6.5, proamniotic cavities are not observed
• however, mutant embryos appear to develop normal ectoplacental cones and extraembryonic membranes and make good contact with the uterus
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reproductive system
• some empty deciduas are noted at E6.5
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