Phenotypes associated with this allele

• Allele Symbol: Cnmd^tm1Ska
• Allele Name: targeted mutation 1, Shigeaki Kato
• Allele ID: MGI:2448465
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnmd^tm1Ska/Cnmd^tm1Ska	involves: C57BL/6 * CBA	MGI:2668179

Genotype
MGI:2668179

hm1

• Allelic Composition: Cnmd^tm1Ska/Cnmd^tm1Ska
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal osteoblast physiology ( J:81137 )

• osteoblast activity is reduced, with a 60% reduction in active osteoblast numbers

skeleton

increased bone mineral density ( J:81137 )

• bone density is increased, however observe no differences in bone or body size and shape

increased bone mineral density of femur ( J:81137 )

• mineral density of femur is about 10% higher than wild-type

increased trabecular bone volume ( J:81137 )

• trabecular bone volume (bone volume per tissue volume) is 2.5-fold higher than in wild-type

abnormal skeleton physiology ( J:81137 )

abnormal osteoblast physiology ( J:81137 )

• osteoblast activity is reduced, with a 60% reduction in active osteoblast numbers

abnormal osteoclast physiology ( J:81137 )

• osteoclast activity is decreased

abnormal bone ossification ( J:81137 )

• mineral apposition rate and bone formation rate are decreased, however embryonic endochondral bone formation and cartilage development are normal

failure of bone resorption ( J:81137 )

• reduction of osteoclast and osteoblast activity resulting in lower bone resorption with respect to bone formation

• more cartilaginous matrix remains in the first spongiosa of tibiae than in wild-type

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:81137 )

immune system

abnormal osteoclast physiology ( J:81137 )

• osteoclast activity is decreased

hematopoietic system

abnormal osteoclast physiology ( J:81137 )

• osteoclast activity is decreased