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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkaa2tm1Vio
targeted mutation 1, Benoit Viollet
MGI:2448466
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prkaa1tm1.1Mfor/Prkaa1tm1.1Mfor
Prkaa2tm1Vio/Prkaa2tm1Vio 		involves: 129S2/SvPas MGI:5527258
cn2
 		Prkaa1tm1Sbj/Prkaa1tm1Sbj
Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Pomc1-cre)1Gsb/0 		involves: 129S2/SvPas * FVB/N MGI:3817316
cn3
 		Prkaa1tm1Sbj/Prkaa1+
Prkaa2tm1Vio/Prkaa2tm1Vio 		involves: 129S2/SvPas * FVB/N MGI:3817315
cn4
 		Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Pomc1-cre)1Gsb/0 		involves: 129S2/SvPas * FVB/N MGI:3817314
cn5
 		Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Alb1-cre)7Gsc/0 		involves: 129S2/SvPas * FVB/N MGI:3817279
cn6
 		Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Agrp-cre)1Gsb/0 		involves: 129S2/SvPas * FVB/N MGI:3817317
cx7
 		Prkaa2tm1Vio/Prkaa2+
Tg(CAG-Tfb1m)AGsha/0 		involves: 129S2/SvPas * C57BL/6J * SJL/J MGI:5789745


Genotype
MGI:5527258
cn1
Allelic
Composition		 Prkaa1tm1.1Mfor/Prkaa1tm1.1Mfor
Prkaa2tm1Vio/Prkaa2tm1Vio
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1tm1.1Mfor mutation (0 available); any Prkaa1 mutation (45 available)
Prkaa2tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:174020 )
N
• primary hepatocytes transfected with a cre-expressing adenovirus exhibit normal glucose production




Genotype
MGI:3817316
cn2
Allelic
Composition		 Prkaa1tm1Sbj/Prkaa1tm1Sbj
Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Pomc1-cre)1Gsb/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1tm1Sbj mutation (2 available); any Prkaa1 mutation (45 available)
Prkaa2tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
Tg(Pomc1-cre)1Gsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:123951 )
• compared to wild-type mice




Genotype
MGI:3817315
cn3
Allelic
Composition		 Prkaa1tm1Sbj/Prkaa1+
Prkaa2tm1Vio/Prkaa2tm1Vio
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa1tm1Sbj mutation (2 available); any Prkaa1 mutation (45 available)
Prkaa2tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:123951 )
• compared to wild-type mice
increased susceptibility to diet-induced obesity ( J:123951 )
• mice exhibit increased diet induced obesity compared to wild-type and Prkaa2tm1Vio/Prkaa2tm1Vio Tg(Pomc1-cre)1Gsb mice

homeostasis/metabolism
increased susceptibility to diet-induced obesity ( J:123951 )
• mice exhibit increased diet induced obesity compared to wild-type and Prkaa2tm1Vio/Prkaa2tm1Vio Tg(Pomc1-cre)1Gsb mice




Genotype
MGI:3817314
cn4
Allelic
Composition		 Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Pomc1-cre)1Gsb/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa2tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
Tg(Pomc1-cre)1Gsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to diet-induced obesity ( J:123951 )
• when fed a high fat diet, mice gain more weight than wild-type mice
abnormal metabolism ( J:123951 )
• mice exhibit reduced resting metabolic rate compared to wild-type mice
• however, daily energy expenditure is normal

growth/size/body
increased body weight ( J:123951 )
• at 11 weeks of age, mice weight 15% more than wild-type mice
increased susceptibility to diet-induced obesity ( J:123951 )
• when fed a high fat diet, mice gain more weight than wild-type mice

nervous system
nervous system phenotype ( J:123951 )
N
• proopiomelanocortin neurons morphology and basal function are normal
abnormal neuron physiology ( J:123951 )
• proopiomelanocortin neurons do not respond electrophysically to glucose as do wild-type cells
• however, the electrophysical responses of proopiomelanocortin neuron to leptin and insulin are normal

adipose tissue
increased percent body fat/body weight ( J:123951 )
• mice exhibit increased adipocity and total body fat compared to wild-type mice

behavior/neurological
increased compensatory feeding amount ( J:123951 )
• mice exhibit increased compensatory feeding compared to wild-type mice after being fasted overnight




Genotype
MGI:3817279
cn5
Allelic
Composition		 Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Alb1-cre)7Gsc/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa2tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating leptin level ( J:108399 )
• mice exhibit an increase in circulating leptin levels in a fasting mouse but leptin levels do not rise when fed unlike wild-type mice
increased circulating glucose level ( J:108399 )
• in a fasting mouse but not in a fed mouse
increased circulating insulin level ( J:108399 )
• in a fasting mouse but not in a fed mouse
abnormal gluconeogenesis ( J:108399 )
• endogenous glucose production is higher than in wild-type mice
• mice fail to exhibit an increase in hepatic glucose production when treated with leptin or adiponectin unlike wild-type mice
• however, mice remain sensitive to the inhibitory effects of hyperinsulinemia on gluconeogenesis and exhibit normal insulin sensitive whole body glucose turnover
increased fatty acids level ( J:108399 )
• in a fasting mouse but not in a fed mouse
increased triglyceride level ( J:108399 )
• in a fasting mouse but not in a fed mouse




Genotype
MGI:3817317
cn6
Allelic
Composition		 Prkaa2tm1Vio/Prkaa2tm1Vio
Tg(Agrp-cre)1Gsb/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa2tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
Tg(Agrp-cre)1Gsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:123951 )
• at 3 months of age, mice display a mild decrease in body weight compared to wild-type mice

nervous system
abnormal neuron physiology ( J:123951 )
• agouti-related protein expressing neurons are slightly more hyperpolarized than in wild-type mice and do not respond electrophysically to glucose as do wild-type cells

behavior/neurological
enhanced behavioral response to xenobiotic ( J:123951 )
• following treatment with melanotan II, mice exhibit less food intake than similarly treated wild-type

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:123951 )
N
• despite reduction in weight, mice exhibit normal food intake, resting metabolic rate, daily energy expenditure, response to a high fat diet, leptin, glucose and adiponectin levels, and glucose and insulin tolerance




Genotype
MGI:5789745
cx7
Allelic
Composition		 Prkaa2tm1Vio/Prkaa2+
Tg(CAG-Tfb1m)AGsha/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkaa2tm1Vio mutation (1 available); any Prkaa2 mutation (35 available)
Tg(CAG-Tfb1m)AGsha mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:228068 )
N
• ABR thresholds are similar to wild-type controls, indicating rescue or delay of the premature hearing loss seen in single Tg(CAG-Tfb1m)AGsha transgenic mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory