About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2rl1tm1Wrf
targeted mutation 1, William R Ferrell
MGI:2448473
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		F2rl1tm1Wrf/F2rl1tm1Wrf involves: 129P2/OlaHsd MGI:3784946
hm2
 		F2rl1tm1Wrf/F2rl1tm1Wrf involves: 129P2/OlaHsd * C57BL/6 MGI:3784945


Genotype
MGI:3784946
hm1
Allelic
Composition		 F2rl1tm1Wrf/F2rl1tm1Wrf
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Wrf mutation (0 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating interleukin-18 level ( J:102762 )
• induction of serum IL-18 following treatment with Propionibacterium acnes and LPS is impaired compared to in similarly treated wild-type mice
abnormal physiological response to xenobiotic ( J:81119 , J:120751 )
• mice fail to reverse ischemia-induced gastrointestinal transit delay induced by SLIGRL-NH2 unlike in wild-type mice (J:81119)
• mice fail to exhibit an increase in abdominal contractions compared to basal distension following exposure to supernatant from patients with irritable bowl syndrome unlike wild-type mice (J:120751)

immune system
decreased circulating interleukin-18 level ( J:102762 )
• induction of serum IL-18 following treatment with Propionibacterium acnes and LPS is impaired compared to in similarly treated wild-type mice
liver inflammation ( J:102762 )
• following treatment with Propionibacterium acnes and LPS, cell infiltration is observed compared to in wild-type mice that develop liver necrosis and granulomas

liver/biliary system
liver inflammation ( J:102762 )
• following treatment with Propionibacterium acnes and LPS, cell infiltration is observed compared to in wild-type mice that develop liver necrosis and granulomas




Genotype
MGI:3784945
hm2
Allelic
Composition		 F2rl1tm1Wrf/F2rl1tm1Wrf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Wrf mutation (0 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:81119 )
• mice fail to exhibit a vasodilation, altered blood pressure or increased synovial joint swelling in response to ASKH95 unlike wild-type mice
• acute inflammatory responses to carageenan/kaolin is reduced compared to in heterozygous (26% decrease) and wild-type mice (40% decrease)
increased cerebral infarct size ( J:112482 )
• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice

nervous system
increased cerebral infarct size ( J:112482 )
• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice

immune system
decreased susceptibility to induced arthritis ( J:81119 )
• chronic joint inflammation is inhibited in mutants

skeleton
decreased susceptibility to induced arthritis ( J:81119 )
• chronic joint inflammation is inhibited in mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory