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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pbsn-FGFR2_iiib*)#Ng
transgene insertion, Norman M Greenberg
MGI:2448655
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0 		involves: FVB MGI:5566522
cx2
 		Tg(Pbsn-FGFR1*K656E)#Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0 		involves: FVB MGI:5566523
tg3
 		Tg(Pbsn-FGFR2_iiib*)#Ng/0 Not Specified MGI:5566516


Genotype
MGI:5566522
cx1
Allelic
Composition		 Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age




Genotype
MGI:5566523
cx2
Allelic
Composition		 Tg(Pbsn-FGFR1*K656E)#Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age
• lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli
• disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment
• neuroendocrine cell population is increased in prostates

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age
• lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli
• disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment
• neuroendocrine cell population is increased in prostates

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age
• lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli
• disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment
• neuroendocrine cell population is increased in prostates




Genotype
MGI:5566516
tg3
Allelic
Composition		 Tg(Pbsn-FGFR2_iiib*)#Ng/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal prostate gland morphology ( J:80821 )
• stroma is disorganized with areas of thickening and hyperplasia and does not form a tight layer of smooth muscle around the epithelial ducts
• increase in numbers of SynP-expressing cells in the basal compartment of the prostate glands, indicating a neuroendocrine phenotype
abnormal prostate gland duct morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
• some of the ducts lack an epithelial lining
abnormal prostate gland epithelium morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
small prostate gland ( J:80821 )
• all four lobes of the prostate are smaller in size

reproductive system
abnormal prostate gland morphology ( J:80821 )
• stroma is disorganized with areas of thickening and hyperplasia and does not form a tight layer of smooth muscle around the epithelial ducts
• increase in numbers of SynP-expressing cells in the basal compartment of the prostate glands, indicating a neuroendocrine phenotype
abnormal prostate gland duct morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
• some of the ducts lack an epithelial lining
abnormal prostate gland epithelium morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
small prostate gland ( J:80821 )
• all four lobes of the prostate are smaller in size




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory