About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pbsn-FGFR2_iiib*)#Ng
transgene insertion, Norman M Greenberg
MGI:2448655
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0 		involves: FVB MGI:5566522
cx2
 		Tg(Pbsn-FGFR1*K656E)#Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0 		involves: FVB MGI:5566523
tg3
 		Tg(Pbsn-FGFR2_iiib*)#Ng/0 Not Specified MGI:5566516


Genotype
MGI:5566522
cx1
Allelic
Composition		 Tg(Arr2/Pbsn-FGFR1K656E)1Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• mice develop high-grade prostate intraepithelial neoplasia (PIN) foci after 6 months of age




Genotype
MGI:5566523
cx2
Allelic
Composition		 Tg(Pbsn-FGFR1*K656E)#Wmck/0
Tg(Pbsn-FGFR2_iiib*)#Ng/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age
• lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli
• disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment
• neuroendocrine cell population is increased in prostates

endocrine/exocrine glands
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age
• lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli
• disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment
• neuroendocrine cell population is increased in prostates

reproductive system
increased prostate intraepithelial neoplasia incidence ( J:87067 )
• develop high-grade prostate intraepithelial neoplasia (PIN) within 8 months of age
• lumen of the gland is filled with multiple layers of atypical epithelial cells with hyperchromatic nuclei and prominent nucleoli
• disruption of basement membrane and microinvasion of epithelial foci in the stromal compartment
• neuroendocrine cell population is increased in prostates




Genotype
MGI:5566516
tg3
Allelic
Composition		 Tg(Pbsn-FGFR2_iiib*)#Ng/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal prostate gland morphology ( J:80821 )
• stroma is disorganized with areas of thickening and hyperplasia and does not form a tight layer of smooth muscle around the epithelial ducts
• increase in numbers of SynP-expressing cells in the basal compartment of the prostate glands, indicating a neuroendocrine phenotype
abnormal prostate gland duct morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
• some of the ducts lack an epithelial lining
abnormal prostate gland epithelium morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
small prostate gland ( J:80821 )
• all four lobes of the prostate are smaller in size

reproductive system
abnormal prostate gland morphology ( J:80821 )
• stroma is disorganized with areas of thickening and hyperplasia and does not form a tight layer of smooth muscle around the epithelial ducts
• increase in numbers of SynP-expressing cells in the basal compartment of the prostate glands, indicating a neuroendocrine phenotype
abnormal prostate gland duct morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
• some of the ducts lack an epithelial lining
abnormal prostate gland epithelium morphology ( J:80821 )
• epithelium of prostatic ducts is disorganized and contains numerous rounded cytokeratin+ cells that are not tightly associated with the basement membrane
small prostate gland ( J:80821 )
• all four lobes of the prostate are smaller in size




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory