Phenotypes associated with this allele

• Allele Symbol: Tg(ITGAL-Hhex)2Hro
• Allele Name: transgene insertion 2, Robert Hromas
• Allele ID: MGI:2448672
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(ITGAL-Hhex)2Hro/0	C3HeB/FeJ-Tg(ITGAL-Hhex)2Hro	MGI:2655918

Genotype
MGI:2655918

tg1

• Allelic Composition: Tg(ITGAL-Hhex)2Hro/0
• Genetic Background: C3HeB/FeJ-Tg(ITGAL-Hhex)2Hro

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal thymus corticomedullary boundary morphology ( J:80777 )

• thymus exhibits loss of the histological demarcation between the medulla and the cortex

thymus hypoplasia ( J:80777 )

abnormal definitive hematopoiesis ( J:80777 )

• percentage of bone marrow CFU-GM (granulocyte-macrophage) in S-phase is increased 2.4-fold while percentage of spleen CFU-GM is increased 18.5-fold; the increase in cycling progenitors is associated with respective increases of 24% and 47% in absolute numbers of CFU-GM in the marrow and spleen

abnormal common myeloid progenitor cell morphology ( J:80777 )

• percentage of bone marrow CFU-GEMM in S-phase is increased 2.7-fold while percentage of spleen CFU-GEMM is increased 40-fold; the increase in cycling progenitors is associated with respective increases of 29% and 80% in absolute numbers of CFU-GEMM in the marrow and spleen

abnormal double-negative T cell morphology ( J:80777 )

• 2-fold decrease in the relative percentage of CD25+CD44- thymocytes in the CD4CD8 double-negative population of T progenitors and a concomitant 2-fold increase in CD25-CD44- cells

increased erythroid progenitor cell number ( J:80777 )

• percentage of bone marrow BFU-E in S-phase is increased 3.1-fold while percentage of spleen BFU-E is increased 23-fold; the increase in cycling progenitors is associated with respective increases of 55% and 94% in absolute numbers of BFU-E in the marrow and spleen

increased CD8-positive, alpha-beta T cell number ( J:80777 )

• 6-fold increase in CD8+ thymocytes

decreased leukocyte cell number ( J:80777 )

• general leukopenia due to decreased T cells in the peripheral blood

decreased lymphocyte cell number ( J:80777 )

• decrease in absolute lymphocytes

decreased T cell number ( J:80777 )

• decrease in peripheral blood T cells, especially CD8+ cells

decreased double-positive T cell number ( J:80777 )

• 1.5-fold decrease in double-positive thymocytes

immune system

abnormal thymus corticomedullary boundary morphology ( J:80777 )

• thymus exhibits loss of the histological demarcation between the medulla and the cortex

thymus hypoplasia ( J:80777 )

abnormal double-negative T cell morphology ( J:80777 )

• 2-fold decrease in the relative percentage of CD25+CD44- thymocytes in the CD4CD8 double-negative population of T progenitors and a concomitant 2-fold increase in CD25-CD44- cells

increased CD8-positive, alpha-beta T cell number ( J:80777 )

• 6-fold increase in CD8+ thymocytes

decreased leukocyte cell number ( J:80777 )

• general leukopenia due to decreased T cells in the peripheral blood

decreased lymphocyte cell number ( J:80777 )

• decrease in absolute lymphocytes

decreased T cell number ( J:80777 )

• decrease in peripheral blood T cells, especially CD8+ cells

decreased double-positive T cell number ( J:80777 )

• 1.5-fold decrease in double-positive thymocytes

endocrine/exocrine glands

abnormal thymus corticomedullary boundary morphology ( J:80777 )

• thymus exhibits loss of the histological demarcation between the medulla and the cortex

thymus hypoplasia ( J:80777 )