Analysis Tools
vision/eye
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• choriocapillaris exhibits loss of fenestrations and focal areas of thickening in 12 month old mice fed a normal or high fat diet
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• degeneration of the retinal pigment epithelium (RPE)
• RPE shows loss of basolateral infoldings and numerous cytoplasmic vacuoles, some of which are filled with membrane-like material, in 12 month old mutants fed a normal diet
• mutants fed a high fat diet do not develop more or larger RPE vacuoles compared to mutants on a normal diet
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• Bruch membrane is thickened in mutants on a normal diet or high-fat diet at 12 months of age
• 12 month old mutants fed a normal diet exhibit basal laminar deposits containing long-spacing collagen in Bruch membrane that are thicker than those in wild-type mice fed a high fat diet
• 50% of mutants on a high fat diet develop basal linear-like deposits within Bruch membrane, however such deposits are not seen in mutants fed a regular diet or in wild-type mice on a high fat diet
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homeostasis/metabolism
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• a high-fat diet does not significantly increase plasma cholesterol levels in mutants as it does in wild-type mice
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cardiovascular system
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• choriocapillaris exhibits loss of fenestrations and focal areas of thickening in 12 month old mice fed a normal or high fat diet
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pigmentation
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• degeneration of the retinal pigment epithelium (RPE)
• RPE shows loss of basolateral infoldings and numerous cytoplasmic vacuoles, some of which are filled with membrane-like material, in 12 month old mutants fed a normal diet
• mutants fed a high fat diet do not develop more or larger RPE vacuoles compared to mutants on a normal diet
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| age related macular degeneration 1 | DOID:0110014 |
OMIM:603075 |
J:151253 | |
