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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(H2-Ea-Il7)10Rhdr
transgene insertion 10, Rhodri Ceredig
MGI:2448707
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Atp11cambr/Y
Tg(H2-Ea-Il7)10Rhdr/0 		involves: C57BL/6 * C57BL/6JApb * DBA/2 MGI:5006961
tg2
 		Tg(H2-Ea-Il7)10Rhdr/0 involves: C57BL/6 MGI:2653628
tg3
 		Tg(H2-Ea-Il7)10Rhdr/0 involves: C57BL/6 * DBA/2 MGI:5006962


Genotype
MGI:5006961
cx1
Allelic
Composition		 Atp11cambr/Y
Tg(H2-Ea-Il7)10Rhdr/0
Genetic
Background		 involves: C57BL/6 * C57BL/6JApb * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation (2 available); any Atp11c mutation (16 available)
Tg(H2-Ea-Il7)10Rhdr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:171924 )
• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes

immune system
decreased B cell number ( J:171924 )
• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes




Genotype
MGI:2653628
tg2
Allelic
Composition		 Tg(H2-Ea-Il7)10Rhdr/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(H2-Ea-Il7)10Rhdr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-negative T cell morphology ( J:81133 )
• 5.3% of double negative cells in 6 week old thymus are CD19+, a significant increase compared to controls
abnormal B cell morphology ( J:81133 )
• proportion of pro/pre-B cells in the thymus is significantly increased

immune system
abnormal double-negative T cell morphology ( J:81133 )
• 5.3% of double negative cells in 6 week old thymus are CD19+, a significant increase compared to controls
abnormal B cell morphology ( J:81133 )
• proportion of pro/pre-B cells in the thymus is significantly increased




Genotype
MGI:5006962
tg3
Allelic
Composition		 Tg(H2-Ea-Il7)10Rhdr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(H2-Ea-Il7)10Rhdr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased pro-B cell number ( J:171924 )
• 5-fold in the bone marrow

hematopoietic system
increased pro-B cell number ( J:171924 )
• 5-fold in the bone marrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory