Phenotypes associated with this allele

• Allele Symbol: Tg(BCL2/IGH)1Tjd
• Allele Name: transgene insertion 1, Timothy J McDonnell
• Allele ID: MGI:2448738
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Il2rg^tm1Krf/Il2rg^tm1Krf Tg(BCL2/IGH)1Tjd/0	either: (involves: 129P2/OlaHsd * C3H/He * C57BL/6) or (involves: 129P2/OlaHsd * C3H/He * C57BL/6 * FVB/N)	MGI:3698154
tg2	Tg(BCL2/IGH)1Tjd/?	involves: C3H/He * C57BL/6	MGI:3698148

Genotype
MGI:3698154

cx1

• Allelic Composition: Il2rg^tm1Krf/Il2rg^tm1Krf; Tg(BCL2/IGH)1Tjd/0
• Genetic Background: either: (involves: 129P2/OlaHsd * C3H/He * C57BL/6) or (involves: 129P2/OlaHsd * C3H/He * C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:114561 )

♀ • mice have about 10-fold fewer thymocytes compared to wild-type mice

hematopoietic system

decreased thymocyte number ( J:114561 )

♀ • mice have about 10-fold fewer thymocytes compared to wild-type mice

endocrine/exocrine glands

decreased thymocyte number ( J:114561 )

♀ • mice have about 10-fold fewer thymocytes compared to wild-type mice

Genotype
MGI:3698148

tg2

• Allelic Composition: Tg(BCL2/IGH)1Tjd/?
• Genetic Background: involves: C3H/He * C57BL/6

immune system

abnormal mononuclear cell differentiation ( J:81147 )

• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls

enlarged spleen ( J:81147 )

• modest enlargement at 20 weeks of age

spleen hyperplasia ( J:81147 )

• extensive hyperplasia of the white pulp zone

increased B cell number ( J:81147 )

• increase in the percentage and absolute number of B cells in the spleen

• however, the absolute number of splenic T cells is similar to controls

increased spleen white pulp amount ( J:81147 )

• expanded white pulp area, primarily containing B cells

• however, the mantle zone is normal, no red pulp invasion is seen, and the geographic distribution of B and T cells within the white pulp is similar to wild-type mice

abnormal B cell physiology ( J:81147 )

• prolonged survival of a subset (about 10% of the total number of cells) of B cells compared to control cells when cultured in DMEM supplemented with only 5% fetal calf serum

• this prolonged survival results in about a 500-fold survival advantage after 14 days in culture

abnormal lymph node morphology ( J:81147 )

• in the para-aortic lymph node the medullary cords and interfollicular area are abnormal with expansion by infiltrates of mixed small and large cleaved follicular center cells, immunoblasts, and plasma cells

enlarged lymph nodes ( J:81147 )

• 2- to 3-fold enlargement of the mesenteric and para-aortic lymph nodes in mice over 15 weeks of age

• however, no enlargement of other regional or peripheral lymph nodes is seen in mice up to 25 weeks of age

hematopoietic system

abnormal mononuclear cell differentiation ( J:81147 )

• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls

enlarged spleen ( J:81147 )

• modest enlargement at 20 weeks of age

spleen hyperplasia ( J:81147 )

• extensive hyperplasia of the white pulp zone

increased B cell number ( J:81147 )

• increase in the percentage and absolute number of B cells in the spleen

• however, the absolute number of splenic T cells is similar to controls

increased spleen white pulp amount ( J:81147 )

• expanded white pulp area, primarily containing B cells

• however, the mantle zone is normal, no red pulp invasion is seen, and the geographic distribution of B and T cells within the white pulp is similar to wild-type mice

abnormal B cell physiology ( J:81147 )

• prolonged survival of a subset (about 10% of the total number of cells) of B cells compared to control cells when cultured in DMEM supplemented with only 5% fetal calf serum

• this prolonged survival results in about a 500-fold survival advantage after 14 days in culture

cellular

abnormal mononuclear cell differentiation ( J:81147 )

• modest increase in the number of splenic mononuclear cells in mice at 8-19 weeks of age compared to controls

growth/size/body

enlarged spleen ( J:81147 )

• modest enlargement at 20 weeks of age

spleen hyperplasia ( J:81147 )

• extensive hyperplasia of the white pulp zone