Phenotypes associated with this allele

• Allele Symbol: Mepe^tm1Tbrw
• Allele Name: targeted mutation 1, Thomas A Brown
• Allele ID: MGI:2448895
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mepe^tm1Tbrw/Mepe^tm1Tbrw	involves: 129P2/OlaHsd * C57BL/6	MGI:3578992
ht2	Mepe^tm1Tbrw/Mepe^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3578993

Genotype
MGI:3578992

hm1

• Allelic Composition: Mepe^tm1Tbrw/Mepe^tm1Tbrw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased trabecular bone in 1 year old Mepe^tm1Tbrw/Mepe⁺ and Mepe^tm1Tbrw/Mepe^tm1Tbrw mice

hematopoietic system

abnormal osteoclast morphology ( J:81218 )

• slight but non significant reduction in osteoclast surface and osteoclast number

skeleton

abnormal osteoclast morphology ( J:81218 )

• slight but non significant reduction in osteoclast surface and osteoclast number

increased trabecular bone volume ( J:81218 )

• increased amount of trabecular bone first noticeable at 4 months of age (50% increase in females, 32% increase in males)

• by 1 year of age males showed a 2-fold increase and females a 3 fold increase

increased osteoblast cell number ( J:81218 )

• 10 month old males had a 2 fold increase in osteoblasts in the distal femur

abnormal skeleton physiology ( J:81218 )

• less aging associated bone loss

• no bone loss in year old males

• females with 15% bone loss at 1 year of age

increased bone mineralization ( J:81218 )

• significant increase in the mineral apposition rate

immune system

abnormal osteoclast morphology ( J:81218 )

• slight but non significant reduction in osteoclast surface and osteoclast number

Genotype
MGI:3578993

ht2

• Allelic Composition: Mepe^tm1Tbrw/Mepe⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Increased trabecular bone in 1 year old Mepe^tm1Tbrw/Mepe⁺ and Mepe^tm1Tbrw/Mepe^tm1Tbrw mice

skeleton

abnormal trabecular bone morphology ( J:81218 )

• Increased amount of trabecular bone first noticeable at 4 months of age (32% increase in males)

• By 1 year of age males showed a 2 fold increase and females a 3 fold increase