Analysis Tools
reproductive system
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• meiotic incompetence in oocytes results in polyploid embryos
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• mutant oocytes cannot correctly position the metaphase spindle during meiosis I and form the first polar body
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• homozygous females ovulate oocytes that fail to progress through metaphase I and to correctly position the metaphase I spindle at the cortex of the oocyte, resulting in the ovulation of oocytes that have not formed the first polar body
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• homozygous females mated to wild-type male exhibit recurrent pregnancy loss during early and mid-gestational stages of development
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• homozygous females rarely carry embryos to term and give birth
• homozygous females mated with wild-type males contain a normal number of uterine decidua but most decidua contain grossly abnormal embryos
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behavior/neurological
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• few pups that are born die from inadequate nursing as a result of a small litter size
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cellular
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• meiotic incompetence in oocytes results in polyploid embryos
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• mutant oocytes cannot correctly position the metaphase spindle during meiosis I and form the first polar body
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• homozygous females ovulate oocytes that fail to progress through metaphase I and to correctly position the metaphase I spindle at the cortex of the oocyte, resulting in the ovulation of oocytes that have not formed the first polar body
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