Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(tetO-cre)LC1Bjd transgene insertion LC1, Hermann Bujard MGI:2448952 |
| Summary |
12 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice treated with 0.5 mg/ml doxycycline for 5 days followed by 0.25 mg/ml doxycycline for 5 days starting at 3 weeks of age do not display abnormalities in calcium or phosphate homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypoxic primary tubular epithelial cells from doxycycline treated mice fails to migrate unlike similarly treated cells from Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1(rtTA)Awu/Gt(ROSA)26Sor+ mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• complete loss of NMDAR-mediated long term potential at dentate gyrus synapses
• however, long term potentiation at Schaffer collateral-CA1 synapses is similar to wild-type mice despite residual Cre activity in CA1 pyramidal cells
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• mice exhibit impaired spatial working memory but normal spatial reference memory in a 3 from 6 radial arm maze task
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal motor coordination and spatial reference memory acquisition in a Morris Water maze
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• mice exhibit impaired spatial reversal learning compared with control mice
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• mice exhibit a small impairment in spatial working memory in an enclosed T maze compared with control mice
• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• less so than Grin2btm1Mony/Grin2btm1Mony Tg(Camk2a-cre)1Gsc mice
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• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice
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• in response to the Grin2b antagonist ifenprodil, mice fail to exhibit a strong reduction in NMDA excitatory postsynaptic currents and faster decay kinetics compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed
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• induced by pentylenetetrazil in mice treated with doxycycline treatment between conception and P21 or not treated with doxycycline at all
• induced by pentylenetetrazil compared with Gabrg2tm2Spet heterozygotes
• doxycycline treatment between conception and P21 increased the time to first clonic seizure compared with mice not treated with doxycycline
• however, no seizure kindling effect is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: visceral, epididymal and subcutaneous white adipose tissue in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal leptin levels
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal leptin levels
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• Background Sensitivity: in an elevated plus maze and open field test, doxycycline-treated mice raised by FVB/J dams exhibit increased anxiety-related behaviors compared with similarly fostered control mice
• however, doxycycline-treated mice fostered by C57BL/6J dams exhibit normal anxiety
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• doxycycline-treated mice raised by C57BL/6J dams exhibit decreased total distance traveled in an open field compared with control mice and doxycycline-treated mice raised by FVB/J dams
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• after doxycycline treatment at P41 and P48, mice raised by FVB/J dams, and to a lesser extent raised by C57BL/6J dams, exhibit slower body weight gain compared with control mice
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• Background Sensitivity: in doxycycline-treated mice raised by FVB/J
• however, doxycycline-treated mice raised by C57BL/6J dams exhibit normal white adipose tissue weight
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal recessive polycystic kidney disease | DOID:0110861 | J:140925 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in primary podocyte cell cultures from doxycycline-treated mice
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• in doxycycline-treated mice
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• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline
• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality
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• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline
• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality
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• in doxycycline-treated mice
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• with vacuolization after 10 days in mice treated with doxycycline
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• reduced density in mice treated with doxycycline
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• from 3 weeks of age, doxycycline-treated mice exhibit focal segmental glomerulosclerosis (FSGS) with adhesions, segmental accumulation of matrix, capillary hyalinosis, loss of capillaries, and declining glomerular numbers through 13 weeks unlike control mice
• however, mice do not develop FSGS when doxycycline is administered antenatally or at 10 and 11 days after birth or when mice are treated with a low dose of doxycycline (1.5 ug/g)
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• in doxycycline-treated mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| focal segmental glomerulosclerosis | DOID:1312 |
OMIM:PS603278 |
J:285673 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
• dividing cells of doxycycline-treated mice during kidney repair show a high shift toward mitotic spindle angles perpendicular to the epithelial plane
• however, doxycline-treated mice exhibit normal kidney histology and function under basal conditions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• progressive in doxycycline-treated mice
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• focal segmental glomerulosclerosis in doxycycline-treated mice
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• progressive in doxycycline-treated mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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