All Phenotypes Lrp5<tm1Jsak> MGI Mouse

decreased insulin secretion ( J:81174 )

• islets show impaired glucose-induced insulin secretion especially at higher concentrations, but this is not due to impairment of ATP

decreased circulating insulin level ( J:81174 )

• mutants on a high-fat diet have lower glucose-stimulated plasma insulin concentrations

impaired glucose tolerance ( J:81174 )

• on a high fat diet, mutants older than 6 months of age display impaired glucose tolerance; younger mutants do not show this

insulin resistance ( J:81174 )

• on a normal diet, homozygotes are not insulin resistant

abnormal calcium ion homeostasis ( J:81174 )

• glucose-induced Ca2+ release in islets is markedly decreased in mutants

increased cholesterol level ( J:81174 )

• plasma cholesterol levels are identical to wild-type when fed a normal chow diet; when fed a high fat diet for 2 months, plasma cholesterol levels are significantly increased (~200 mg/dl vs ~170 mg/dl)

increased circulating VLDL cholesterol level ( J:81174 )

• levels are increased in mutants fed a high fat diet

decreased insulin secretion ( J:81174 )

• islets show impaired glucose-induced insulin secretion especially at higher concentrations, but this is not due to impairment of ATP

abnormal limb morphology ( J:81174 )

• pathological fractures of lower limbs are seen in some mutants

abnormal femur morphology ( J:81174 )

• in females older than 6 months, femur bone is thin and fragile

decreased diameter of femur ( J:81174 )

decreased diameter of tibia ( J:81174 )

• thickness of tibias in female mutants is reduced to 60-70% of controls

thin parietal bone ( J:81174 )

• in females older than 6 months, parietal bone is thin and fragile

• thickness of parietal portion of calvaria is reduced to 50-60% of controls

abnormal liver physiology ( J:81174 )

• hepatic uptake and clearance of chylomicron remnants is markedly reduced in mutants to ~16% of wild-type levels