All Phenotypes Tg(ACTFLPe)9205Dym MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(ACTFLPe)9205Dym
transgene insertion 9205, Susan Dymecki
MGI:2448985

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ Tg(ACTFLPe)9205Dym/0 Tg(Pcp2-cre)2Mpin/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL	MGI:4412292
cn2	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ En1^tm2(cre)Wrst/En1⁺ Tg(ACTFLPe)9205Dym/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL	MGI:4412289
cn3	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ Tg(ACTFLPe)9205Dym/0 Tg(Atoh1-cre)1Bfri/0	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	MGI:4412287
cn4	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/0 Tg(ACTFLPe)9205Dym/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:4412288
cn5	Psmd11^tm1.1Qit/Psmd11^tm1.1Qit Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa}/Gt(ROSA)26Sor⁺ Tg(ACTFLPe)9205Dym/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:7643474
cn6	Tie1^tm1Geno/Tie1^tm1Geno Tg(ACTFLPe)9205Dym/0	involves: C57BL/6 * ICR * SJL	MGI:4454553

Allelic Composition	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ Tg(ACTFLPe)9205Dym/0 Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(ACTFLPe)9205Dym mutation (7 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:154944 )

• mild tremors during motion

Allelic Composition	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ En1^tm2(cre)Wrst/En1⁺ Tg(ACTFLPe)9205Dym/0
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(ACTFLPe)9205Dym mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:154944 )

Allelic Composition	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ Tg(ACTFLPe)9205Dym/0 Tg(Atoh1-cre)1Bfri/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired balance ( J:154944 )

impaired coordination ( J:154944 )

abnormal gait ( J:154944 )

• aberrant foot print angles, irregular and reduced stride lengths

short stride length ( J:154944 )

nervous system

abnormal synaptic vesicle recycling ( J:154944 )

• parallel fibers accumulate unreleased synaptic vesicles unlike in wild-type cells

abnormal excitatory postsynaptic currents ( J:154944 )

• stimulation of parallel fibers fails to stimulate an excitatory postsynaptic current (EPSC) unlike in similarly treated wild-type mice

• however, extremely high stimulus intensities evoke an EPSC and stimulated parallel fibers propagate action potentials normally

hearing/vestibular/ear

abnormal ear physiology ( J:154944 )

• mice exhibit auditory defects

Allelic Composition	Gt(ROSA)26Sor^{tm7(CAG-mCherry,-EGFP/tetX)Dym}/Gt(ROSA)26Sor⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/0 Tg(ACTFLPe)9205Dym/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:154944 )

Allelic Composition	Psmd11^tm1.1Qit/Psmd11^tm1.1Qit Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa}/Gt(ROSA)26Sor⁺ Tg(ACTFLPe)9205Dym/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(CAG-Cre/ERT2)Dsa} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Psmd11^tm1.1Qit mutation (0 available); any Psmd11 mutation (41 available)
Tg(ACTFLPe)9205Dym mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased apoptosis ( J:301736 )

• mouse embryonic fibroblasts (MEFs) from E14.5 embryos treated with 4-hydroxytamoxifen to induce deletion of the floxed Psmd11 allele exhibit increased apoptosis

Allelic Composition	Tie1^tm1Geno/Tie1^tm1Geno Tg(ACTFLPe)9205Dym/0
Genetic Background	involves: C57BL/6 * ICR * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTFLPe)9205Dym mutation (7 available)
Tie1^tm1Geno mutation (0 available); any Tie1 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:159507 )

N	• mice exhibit normal lymphangiogenesis

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