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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag1tm1Bal
targeted mutation 1, David Baltimore
MGI:2448994
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Lattm2.1Mal/Lattm2.1Mal
Rag1tm1Bal/Rag1tm1Bal 		involves: 129S2/SvPas * 129S4/SvJae MGI:3770648
cx2
 		Lattm1.1Mal/Lattm1.1Mal
Rag1tm1Bal/Rag1tm1Bal 		involves: 129S2/SvPas * 129S4/SvJae MGI:3770649
cx3
 		Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb 		involves: 129S4/SvJae * 129S8/SvEv MGI:3689310
cx4
 		Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
Tg(TcrAND)53Hed/0 		involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL MGI:3689309
cx5
 		Rag1tm1Bal/Rag1tm1Bal
Tg(TcraTcrb)1100Mjb/? 		involves: 129S4/SvJae * C57BL/6 MGI:3783835
cx6
 		C1galt1ptl1/C1galt1ptl1
Rag1tm1Bal/Rag1tm1Bal 		involves: 129S4/SvJae * C57BL/6 MGI:3723642
cx7
 		Rag1tm1Bal/Rag1tm1Bal
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl 		involves: 129/Sv * C57BL/6 MGI:3053736


Genotype
MGI:3770648
cx1
Allelic
Composition		 Lattm2.1Mal/Lattm2.1Mal
Rag1tm1Bal/Rag1tm1Bal
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm2.1Mal mutation (0 available); any Lat mutation (10 available)
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased platelet aggregation ( J:125744 )
• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen
abnormal platelet dense granule physiology ( J:125744 )
• platelet-dense granule secretion is absent in response to low doses of the clotting agonist

homeostasis/metabolism
decreased platelet aggregation ( J:125744 )
• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen
abnormal platelet dense granule physiology ( J:125744 )
• platelet-dense granule secretion is absent in response to low doses of the clotting agonist
abnormal thrombosis ( J:125744 )
• platelets are unable to form a multilayered thrombi on collagen coated surfaces




Genotype
MGI:3770649
cx2
Allelic
Composition		 Lattm1.1Mal/Lattm1.1Mal
Rag1tm1Bal/Rag1tm1Bal
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm1.1Mal mutation (0 available); any Lat mutation (10 available)
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased platelet aggregation ( J:125744 )
• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen
• however, platelets do aggregate in response to low doses of thrombin
abnormal platelet dense granule physiology ( J:125744 )
• platelet-dense granule secretion is absent in response to low doses of the clotting agonist

homeostasis/metabolism
decreased platelet aggregation ( J:125744 )
• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen
• however, platelets do aggregate in response to low doses of thrombin
abnormal platelet dense granule physiology ( J:125744 )
• platelet-dense granule secretion is absent in response to low doses of the clotting agonist




Genotype
MGI:3689310
cx3
Allelic
Composition		 Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
Genetic
Background		 involves: 129S4/SvJae * 129S8/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Vav1tm2Tyb mutation (0 available); any Vav1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
arrested T cell differentiation ( J:113270 )
• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone

hematopoietic system
arrested T cell differentiation ( J:113270 )
• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone




Genotype
MGI:3689309
cx4
Allelic
Composition		 Rag1tm1Bal/Rag1tm1Bal
Vav1tm2Tyb/Vav1tm2Tyb
Tg(TcrAND)53Hed/0
Genetic
Background		 involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Tg(TcrAND)53Hed mutation (2 available)
Vav1tm2Tyb mutation (0 available); any Vav1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:113270 )
• reduced percentage of CD4+ cells compared to mice wild-type for Vav1

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:113270 )
• reduced percentage of CD4+ cells compared to mice wild-type for Vav1




Genotype
MGI:3783835
cx5
Allelic
Composition		 Rag1tm1Bal/Rag1tm1Bal
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD8-positive, alpha-beta T cell number ( J:133645 )
• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen
abnormal CD4-positive, alpha beta T cell morphology ( J:133645 )
• many of the CD4 T cells express the transgenic TCR alpha chain
decreased CD4-positive, alpha-beta T cell number ( J:133645 )
• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen

hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:133645 )
• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen
abnormal CD4-positive, alpha beta T cell morphology ( J:133645 )
• many of the CD4 T cells express the transgenic TCR alpha chain
decreased CD4-positive, alpha-beta T cell number ( J:133645 )
• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen




Genotype
MGI:3723642
cx6
Allelic
Composition		 C1galt1ptl1/C1galt1ptl1
Rag1tm1Bal/Rag1tm1Bal
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1ptl1 mutation (0 available); any C1galt1 mutation (26 available)
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Premature death and kidney disease in C1galt1ptl1/C1galt1ptl1 and C1galt1ptl1/C1galt1ptl1 Rag1tm1Bal/Rag1tm1Bal mice

mortality/aging
premature death ( J:115272 )
• mutants become ill, develop kidney disease and most are moribund by 200 days

renal/urinary system
kidney inflammation ( J:115272 )
• extensive inflammatory infiltration
abnormal kidney morphology ( J:115272 )
• renal lesions
decreased renal glomerulus number ( J:115272 )
• loss of glomeruli
abnormal renal tubule morphology ( J:115272 )
• tubular disorganization

hematopoietic system
thrombocytopenia ( J:115272 )
• thrombocytopenia
increased mean platelet volume ( J:115272 )
• high platelet volume

homeostasis/metabolism

immune system
kidney inflammation ( J:115272 )
• extensive inflammatory infiltration




Genotype
MGI:3053736
cx7
Allelic
Composition		 Rag1tm1Bal/Rag1tm1Bal
Tnfrsf1atm1.1Gkl/Tnfrsf1atm1.1Gkl
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Tnfrsf1atm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen compared to Tnfrsf1atm1Gkl in homozygotes

liver/biliary system
liver inflammation ( J:92470 )
• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood
• no change in the severity of liver inflammation is seen compared to Tnfrsf1atm1Gkl in homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory