Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cenpetm2Dwc mutation
(0 available);
any
Cenpe mutation
(109 available)
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cellular
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• following liver injury, hepatocytes from mutants treated with an adenoviral cre, exhibit abnormal mitosis with misaligned, centrophilic chromosomes
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• chromosomal instability is observed during liver regeneration after injury in hepatocytes from mutants treated with an adenoviral cre
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liver/biliary system
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• following liver injury, hepatocytes from mutants treated with an adenoviral cre, exhibit abnormal mitosis with misaligned, centrophilic chromosomes
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cenpetm1Dwc mutation
(0 available);
any
Cenpe mutation
(109 available)
Cenpetm2Dwc mutation
(0 available);
any
Cenpe mutation
(109 available)
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cellular
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• fibroblasts infected with adenovirus encoding cre show mitotic abnormalities with defects in chromosome alignments; in some cases, one or two chromosomes are displaced from the metaphase plate, in other cases chromosomes fail to align or are clustered near the poles in a centrophilic position
• percentage of mitotic cells with misaligned chromosomes increases over time, from 28% at 24 hours postinfection with adenovirus encoding cre to 43% at 48 hours postinfection
• misaligned chromosomes result from a failure of chromosomes to congress, not from premature sister chromatid separation
• fibroblasts grown in vitro show a reduced number of kinetochore-associated microtubules
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Analysis Tools