Phenotypes associated with this allele

• Allele Symbol: Itgb1bp2^tm1Tron
• Allele Name: targeted mutation 1, Guido Tarone
• Allele ID: MGI:2449013
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb1bp2^tm1Tron/Itgb1bp2^tm1Tron	involves: 129S1/Sv * 129X1/SvJ	MGI:2654574
ot2	Itgb1bp2^tm1Tron/Y	involves: 129S1/Sv * 129X1/SvJ	MGI:2654577

Genotype
MGI:2654574

hm1

• Allelic Composition: Itgb1bp2^tm1Tron/Itgb1bp2^tm1Tron
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:81163 )

♀ • lethality rates at 4 weeks after TAC are greater (53.3% vs. 30.7%) than in wild-type

cardiovascular system

abnormal response of heart to induced stress ( J:81163 )

♀ • mutants subjected to pressure overload induced by transversial aortic coarctation (TAC) develop abnormal cardiac remodeling that evolves into dilated cardiomyopathy and contractile dysfunction, with a typical pattern of eccentric hypertrophic remodeling instead of a concentric hypertrophy as in wild-type mice

♀ • however, hypertrophic response is similar to wild-type after chronic administration of angiotensin II or phenylephrine (that is, in the absence of mechanical stress) at doses that do not increase blood pressure

homeostasis/metabolism

abnormal response of heart to induced stress ( J:81163 )

♀ • mutants subjected to pressure overload induced by transversial aortic coarctation (TAC) develop abnormal cardiac remodeling that evolves into dilated cardiomyopathy and contractile dysfunction, with a typical pattern of eccentric hypertrophic remodeling instead of a concentric hypertrophy as in wild-type mice

♀ • however, hypertrophic response is similar to wild-type after chronic administration of angiotensin II or phenylephrine (that is, in the absence of mechanical stress) at doses that do not increase blood pressure

Genotype
MGI:2654577

ot2

• Allelic Composition: Itgb1bp2^tm1Tron/Y
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:81163 )

♂ • lethality rates at 4 weeks after TAC are greater (53.3% vs. 30.7%) than in wild-type

cardiovascular system

abnormal response of heart to induced stress ( J:81163 )

♂ • mutants subjected to pressure overload induced by transversial aortic coarctation (TAC) develop abnormal cardiac remodeling that evolves into dilated cardiomyopathy and contractile dysfunction, with a typical pattern of eccentric hypertrophic remodeling instead of a concentric hypertrophy as in wild-type mice

♂ • however, hypertrophic response is similar to wild-type after chronic administration of angiotensin II or phenylephrine (that is, in the absence of mechanical stress) at doses that do not increase blood pressure

homeostasis/metabolism

abnormal response of heart to induced stress ( J:81163 )

♂ • mutants subjected to pressure overload induced by transversial aortic coarctation (TAC) develop abnormal cardiac remodeling that evolves into dilated cardiomyopathy and contractile dysfunction, with a typical pattern of eccentric hypertrophic remodeling instead of a concentric hypertrophy as in wild-type mice

♂ • however, hypertrophic response is similar to wild-type after chronic administration of angiotensin II or phenylephrine (that is, in the absence of mechanical stress) at doses that do not increase blood pressure