Phenotypes associated with this allele

• Allele Symbol: Vamp1^lew
• Allele Name: lethal wasting
• Allele ID: MGI:2449158
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vamp1^lew/Vamp1^lew	involves: C3H/HeSnJ	MGI:2449162
hm2	Vamp1^lew/Vamp1^lew	involves: C3H/HeSnJ * CAST/EiJ	MGI:3845978

Genotype
MGI:2449162

hm1

• Allelic Composition: Vamp1^lew/Vamp1^lew
• Genetic Background: involves: C3H/HeSnJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:81354 )

• mutants die by 3 weeks of age

behavior/neurological

abnormal posture ( J:81354 )

• mutants lie on their sides with their front paws curled inward and their back legs held tightly together

growth/size/body

decreased body size ( J:81354 )

• mutants can be recognized at 2 weeks by their small size (about 30% smaller than littermates)

Genotype
MGI:3845978

hm2

• Allelic Composition: Vamp1^lew/Vamp1^lew
• Genetic Background: involves: C3H/HeSnJ * CAST/EiJ

mortality/aging

postnatal lethality ( J:148602 )

• affected mice die at around 15 days of age

behavior/neurological

impaired righting response ( J:148602 )

• 10 day old mice do not attempt to right themselves when place on their backs

impaired limb coordination ( J:148602 )

• limb movement occurs in 10 day old mice but is not effective

abnormal posture ( J:148602 )

• 10 day old mice lay on their side

akinesia ( J:148602 )

• noticably immobile at 10 days of age