Phenotypes associated with this allele

• Allele Symbol: Sbf1^tm1Mlc
• Allele Name: targeted mutation 1, Michael L Cleary
• Allele ID: MGI:2449174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sbf1^tm1Mlc/Sbf1^tm1Mlc	involves: C57BL/6	MGI:2449977

Genotype
MGI:2449977

hm1

• Allelic Composition: Sbf1^tm1Mlc/Sbf1^tm1Mlc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Failure of spermatogenesis in Sbf1^tm1Mlc/Sbf1^tm1Mlc mice

cellular

azoospermia ( J:76406 )

♂ • no mature sperm

abnormal spermatid morphology ( J:76406 )

♂ • decreased number of round spermatids and very few elongated spermatids

mortality/aging

postnatal lethality, incomplete penetrance ( J:76406 )

• Background Sensitivity: males from backcross generations display reduced viability at 3 weeks; not observed in homozygous mutants from intercross

reproductive system

reproductive system phenotype ( J:76406 )

N • normal mating behavior

N • normal appearance of external genitalia

abnormal seminiferous tubule morphology ( J:76406 )

♂ • extensive vacuolization of seminiferous tubules in adult testes

small testis ( J:76406 )

♂ • reduced testis size and weight in males

abnormal spermatogenesis ( J:76406 )

♂ • progressive spermatogenic failure

azoospermia ( J:76406 )

♂ • no mature sperm

abnormal spermatid morphology ( J:76406 )

♂ • decreased number of round spermatids and very few elongated spermatids

male infertility ( J:76406 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:76406 )

N • normal serum levels of follicle stimulating hormone, leutenizing hormone, and testosterone

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:76406 )

♂ • extensive vacuolization of seminiferous tubules in adult testes

small testis ( J:76406 )

♂ • reduced testis size and weight in males