Phenotypes associated with this allele

• Allele Symbol: Plcg2^tm1Kuro
• Allele Name: targeted mutation 1, Tomohiro Kurosaki
• Allele ID: MGI:2449276
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Plcg2^tm1Kuro/Plcg2^tm1Kuro Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:3777293

Genotype
MGI:3777293

cn1

• Allelic Composition: Plcg2^tm1Kuro/Plcg2^tm1Kuro; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:63744 )

N • T cell proliferation in response to anti-CD3 antibodies is normal

decreased B cell proliferation ( J:63744 )

• when stimulated by anti-IgM or anti-IgM and IL-4, B cell proliferation is reduced 10-fold

• however, proliferation in response to anti-CD40 antibodies is normal

increased immature B cell number ( J:63744 )

• the number of IgM high IgD low immature B cells in the bone marrow is increased compared to in heterzygotes

increased pro-B cell number ( J:63744 )

• the number of B220+CD43+IgM- pro-B cells in the bone marrow is increased compared to in heterozygotes

decreased mature B cell number ( J:63744 )

• the number of B220+IgM+ mature B cells in the spleen, bone marrow, and lymph nodes is reduced 2- to 3-fold compared to in heterozygous mice

• the number of IgM low IgD high mature B cells in the bone marrow is reduced compared to in heterozygotes

increased B-1a cell number ( J:63744 )

decreased pre-B cell number ( J:63744 )

• the number of B220+CD43-IgM- pre-B cells in the bone marrow is decreased compared to in heterozygotes

abnormal humoral immune response ( J:63744 )

• anti-TNP IgM responses to a T cell-dependent and -independent antigen are reduced

• however, anti-TNP IgG responses are normal

hematopoietic system

decreased B cell proliferation ( J:63744 )

• when stimulated by anti-IgM or anti-IgM and IL-4, B cell proliferation is reduced 10-fold

• however, proliferation in response to anti-CD40 antibodies is normal

increased immature B cell number ( J:63744 )

• the number of IgM high IgD low immature B cells in the bone marrow is increased compared to in heterzygotes

increased pro-B cell number ( J:63744 )

• the number of B220+CD43+IgM- pro-B cells in the bone marrow is increased compared to in heterozygotes

decreased mature B cell number ( J:63744 )

• the number of B220+IgM+ mature B cells in the spleen, bone marrow, and lymph nodes is reduced 2- to 3-fold compared to in heterozygous mice

• the number of IgM low IgD high mature B cells in the bone marrow is reduced compared to in heterozygotes

increased B-1a cell number ( J:63744 )

decreased pre-B cell number ( J:63744 )

• the number of B220+CD43-IgM- pre-B cells in the bone marrow is decreased compared to in heterozygotes

cellular

decreased B cell proliferation ( J:63744 )

• when stimulated by anti-IgM or anti-IgM and IL-4, B cell proliferation is reduced 10-fold

• however, proliferation in response to anti-CD40 antibodies is normal