Phenotypes associated with this allele

• Allele Symbol: Pck1^tm1.2Mgn
• Allele Name: targeted mutation 1.2, Mark A Magnuson
• Allele ID: MGI:2449284
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pck1^tm1.2Mgn/Pck1^tm1.2Mgn	involves: 129S6/SvEvTac	MGI:3029209
ht2	Pck1^tm1Mgn/Pck1^tm1.2Mgn	involves: 129S6/SvEvTac	MGI:3029210

Genotype
MGI:3029209

hm1

• Allelic Composition: Pck1^tm1.2Mgn/Pck1^tm1.2Mgn
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:63929 )

• all homozygous pups die within 3 days of birth

behavior/neurological

lethargy ( J:63929 )

• homozygous animals became lethargic prior to death

absent gastric milk in neonates ( J:63929 )

• animals did not feed as demonstrated by a lack of milk in the stomach

growth/size/body

decreased body size ( J:63929 )

• animals are described as smaller than controls

homeostasis/metabolism

hypoglycemia ( J:63929 )

• low plasma glucose concentrations compared to controls

decreased liver glycogen level ( J:63929 )

• hepatic glycogen content was reduced in homozygous animals after birth

liver/biliary system

decreased liver glycogen level ( J:63929 )

• hepatic glycogen content was reduced in homozygous animals after birth

pale liver ( J:63929 )

integument

pallor ( J:63929 )

• animals are described as pale

Genotype
MGI:3029210

ht2

• Allelic Composition: Pck1^tm1Mgn/Pck1^tm1.2Mgn
• Genetic Background: involves: 129S6/SvEvTac

liver/biliary system

enlarged liver ( J:63929 )

• after a 24 hour fast, the liver mass was increased by 65% over controls

pale liver ( J:63929 )

growth/size/body

enlarged liver ( J:63929 )

• after a 24 hour fast, the liver mass was increased by 65% over controls