Phenotypes associated with this allele

• Allele Symbol: Igf1^tm1.1Dlr
• Allele Name: targeted mutation 1.1, Derek LeRoith
• Allele ID: MGI:2449287
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1^tm1.1Dlr/Igf1^tm1.1Dlr	involves: C57BL/6 * FVB/N	MGI:3818437
cx2	Igf1^tm1.1Dlr/Igf1^tm1.1Dlr Tg(Ttr-IGF1)1Sykr/0	FVB.Cg-Igf1^tm1.1Dlr Tg(Ttr-IGF1)1Sykr	MGI:4455335

Genotype
MGI:3818437

hm1

• Allelic Composition: Igf1^tm1.1Dlr/Igf1^tm1.1Dlr
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:49468 )

• some survive up to 4-6 weeks of age

postnatal lethality, incomplete penetrance ( J:69518 )

• postnatal survival rate of 42%

prenatal lethality, incomplete penetrance ( J:69518 )

• 31% prenatal lethality

growth/size/body

decreased birth weight ( J:69518 )

• weight at birth is 65% of controls

abnormal body size ( J:69518 )

slow postnatal weight gain ( J:49468 , J:69518 )

• severe growth retardation (J:49468)

• weight at 3 weeks of age 4.5 grams (J:49468)

• 50% of control weight at 2 weeks (J:69518)

• 30% of control weight at 8 weeks (J:69518)

decreased body length ( J:69518 )

• 2/3 control length at 8 weeks

homeostasis/metabolism

increased circulating growth hormone level ( J:69518 )

• elevated 12.5 fold at 5 weeks of age

abnormal glucose homeostasis ( J:69518 )

decreased circulating glucose level ( J:69518 )

• decreased by 50% after 24 hour fast

increased circulating insulin level ( J:69518 )

• after 24 hour fast

insensitivity to growth hormone ( J:69518 )

• except for a 16% increase in liver weight

Genotype
MGI:4455335

cx2

• Allelic Composition: Igf1^tm1.1Dlr/Igf1^tm1.1Dlr; Tg(Ttr-IGF1)1Sykr/0
• Genetic Background: FVB.Cg-Igf1^tm1.1Dlr Tg(Ttr-IGF1)1Sykr

mortality/aging

mortality/aging ( J:157350 )

N • mice are born in normal Mendelian ratios

reproductive system

abnormal corpus luteum morphology ( J:157350 )

♀ • hypoplastic

abnormal mature ovarian follicle morphology ( J:157350 )

♀ • mice have few mature graafian follicles

ovary hypoplasia ( J:157350 )

♀

abnormal endometrium morphology ( J:157350 )

♀ • mice exhibit immature endometrial epithelium compared with wild-type mice

abnormal endometrial gland development ( J:157350 )

♀ • mice exhibit little glandular development compared with wild-type mice

decreased endometrial gland number ( J:157350 )

♀

endometrium hypoplasia ( J:157350 )

♀

myometrium hypoplasia ( J:157350 )

♀

increased superovulation rate ( J:157350 )

♀ • following hormone treatment, more eggs are released compared to in similarly treated wild-type mice

abnormal estrous cycle ( J:157350 )

♀ • irregular with prolonged diesterus and proesterus and shortened estrus

prolonged diestrus ( J:157350 )

♀

short estrus ( J:157350 )

♀

prolonged proestrus ( J:157350 )

♀

reduced female fertility ( J:157350 )

♀ • breeding of female mice is largely unsuccessful compared with wild-type mice

decreased litter size ( J:157350 )

• from female mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:157350 )

N • mice exhibit normal fasting glucose and glucose clearance

decreased circulating insulin level ( J:157350 )

• mice exhibit a tend towards reduced serum insulin levels compared with wild-type mice

abnormal insulin-like growth factor I level ( J:157350 )

• mice exhibit increased endocrine IGF-I levels compared with wild-type mice

increased circulating insulin-like growth factor I level ( J:157350 )

• 3-fold from 2 to 16 weeks of age

growth/size/body

decreased birth body size ( J:157350 )

• at birth, mice are smaller than wild-type mice

• however, body weight is normalized by 2 weeks of age

increased body length ( J:157350 )

• at 4 weeks of age, mice exhibit decreased body length compared with wild-type mice

• however, body length is normalized later on during growth and femur length is normal at 16 weeks of age

increased spleen weight ( J:157350 )

adipose tissue

decreased total body fat amount ( J:157350 )

• at 4 but not 8 weeks

decreased gonadal fat pad weight ( J:157350 )

decreased percent body fat/body weight ( J:157350 )

• at 4 and 8 weeks but not 16 weeks

hematopoietic system

increased spleen weight ( J:157350 )

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:157350 )

♀ • mice exhibit increased ductal branching compared to in wild-type mice

abnormal endometrial gland development ( J:157350 )

♀ • mice exhibit little glandular development compared with wild-type mice

decreased endometrial gland number ( J:157350 )

♀

abnormal corpus luteum morphology ( J:157350 )

♀ • hypoplastic

abnormal mature ovarian follicle morphology ( J:157350 )

♀ • mice have few mature graafian follicles

ovary hypoplasia ( J:157350 )

♀

immune system

increased spleen weight ( J:157350 )

integument

abnormal branching of the mammary ductal tree ( J:157350 )

♀ • mice exhibit increased ductal branching compared to in wild-type mice