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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm2(AGT)Sig
targeted mutation 2, Curt Sigmund
MGI:2449453
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hprt1tm2(AGT)Sig/Hprt1tm2(AGT)Sig involves: 129P2/OlaHsd * C57BL/6J MGI:3720727
cx2
 		Hprt1tm2(AGT)Sig/Hprt1tm2(AGT)Sig
Tg(hAGT)2041Sig/? 		involves: 129P2/OlaHsd * C57BL/6 * SJL/J MGI:3720717
cx3
 		Hprt1tm2(AGT)Sig/Y
Tg(hAGT)2041Sig/? 		involves: 129P2/OlaHsd * C57BL/6 * SJL/J MGI:3720718
ot4
 		Hprt1tm2(AGT)Sig/Y involves: 129P2/OlaHsd * C57BL/6J MGI:3720728


Genotype
MGI:3720727
hm1
Allelic
Composition		 Hprt1tm2(AGT)Sig/Hprt1tm2(AGT)Sig
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased systemic arterial blood pressure ( J:81515 )
• after administration of human angiotensin protein, blood pressure is increased by 25.6+/-2.0 mmHg compared to control mice




Genotype
MGI:3720717
cx2
Allelic
Composition		 Hprt1tm2(AGT)Sig/Hprt1tm2(AGT)Sig
Tg(hAGT)2041Sig/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1279 available)
Tg(hAGT)2041Sig mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:81310 )
• females exhibit an increase in heart weight-to-body weight relative to controls

growth/size/body
increased heart weight ( J:81310 )
• females exhibit an increase in heart weight-to-body weight relative to controls




Genotype
MGI:3720718
cx3
Allelic
Composition		 Hprt1tm2(AGT)Sig/Y
Tg(hAGT)2041Sig/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1279 available)
Tg(hAGT)2041Sig mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased systemic arterial blood pressure ( J:81310 )
• males exhibit an increase in blood pressure of 9.7+/-0.9 mmHg compared to control littermates




Genotype
MGI:3720728
ot4
Allelic
Composition		 Hprt1tm2(AGT)Sig/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(AGT)Sig mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased systemic arterial blood pressure ( J:81515 )
• after administration of human angiotensin protein, blood pressure is increased by 25.6+/-2.0 mmHg compared to control mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory